DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ALSST
Uniprot ID:
Q9UBF2
Source protein:
Coatomer subunit gamma-2
Source gene:
COPG2
Class:
DEG_SPOP_SBC_1
Location:
787:791
E3 ligase:
SPOP
DEGRON score:
0.7115
ASA_SCORE:
59.16
COIL:
0.627
CONS_SCORE:
0.4243
DSS_SCORE:
0.3755
HELIX:
0.0984
FCONS_SCORE:
1.0063
RIG_SCORE:
0.804
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with COPG2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ALSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
1048:1052
ALSST
SPOP
0.9809
More...
Q96GC6
Neurotrophin receptor-interacting factor homolog
DEG_SPOP_SBC_1
362:366
ALSST
SPOP
0.8364
More...
Q96T23
Remodeling and spacing factor 1
DEG_SPOP_SBC_1
555:559
ALSST
SPOP
0.6085
More...
Q9UBF2
Coatomer subunit gamma-2
DEG_SPOP_SBC_1
787:791
ALSST
SPOP
0.7115
More...
Q9Y5Y4
Prostaglandin D2 receptor 2
DEG_SPOP_SBC_1
389:393
ALSST
SPOP
0.9088
More...
Q7L1V2
Vacuolar fusion protein MON1 homolog B
DEG_SPOP_SBC_1
68:72
ALSST
SPOP
0.6448
More...
Q92576
PHD finger protein 3
DEG_SPOP_SBC_1
1158:1162
ALSST
SPOP
0.997
More...