DegronMD - P13611(VCAN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T643I	TCGA-05-4382	LUAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7078
p.T643I	DO24900	LUAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7078
p.S1767T	TCGA-14-1458	GBM	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.2778
p.S1767T	DO13851	GBM	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.2778
p.F1754I	TCGA-17-Z022	LUAD	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.F1754I	TCGA-17-Z022	LUAD	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1389
p.S1050I	TCGA-17-Z045	LUAD	TCGA	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.7341
p.L2787F	TCGA-17-Z045	LUAD	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2778
p.P3059S	TCGA-18-3409	LUSC	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5641
p.P3059S	DO26444	LUSC	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5641
p.P644S	TCGA-21-1079	LUSC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.6752
p.P644S	DO26846	LUSC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.6752
p.E3054D	TCGA-21-5787	LUSC	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.3056
p.E3054D	DO26605	LUSC	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.3056
p.D3070N	TCGA-2W-A8YY	CESC	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.0833
p.D3070N	DO223732	CESC	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.0833
p.P2185Q	TCGA-39-5034	LUSC	TCGA	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.25
p.P2185Q	DO26854	LUSC	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.25
p.E2794Q	TCGA-44-2656	LUAD	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.5633
p.E2794Q	DO26052	LUAD	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.5633
p.Q1532L	TCGA-49-AARE	LUAD	TCGA	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1111
p.Q1532L	DO218922	LUAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1111
p.V1856L	TCGA-50-5930	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1111
p.V1856L	DO25189	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1111
p.K878E	TCGA-55-7725	LUAD	TCGA	PTTST	DEG_SPOP_SBC_1	885:889	Mutation substituting flanking lysine	0.25
p.K878E	DO24636	LUAD	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation substituting flanking lysine	0.25
p.G2970V	TCGA-56-7823	LUSC	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.G2970V	DO223721	LUSC	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.T1848S	TCGA-64-1679	LUAD	TCGA	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.6005
p.T1848S	DO26200	LUAD	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.6005
p.E2800D	TCGA-66-2767	LUSC	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2778
p.E2800D	TCGA-66-2767	LUSC	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.2222
p.E2800D	DO26713	LUSC	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2778
p.E2800D	DO26713	LUSC	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.2222
p.P53T	TCGA-78-7539	LUAD	TCGA	PPSY	ITCH	53:56	Mutation altering degron motif	0.7031
p.P53T	DO26210	LUAD	ICGC	PPSY	ITCH	53:56	Mutation altering degron motif	0.7031
p.T632K	TCGA-95-A4VP	LUAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1111
p.T632K	DO51201	LUAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1111
p.I2335S	TCGA-A5-A0G2	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.2222
p.I2335S	DO41235	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.2222
p.S1712Y	TCGA-A5-A2K5	UCEC	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.0833
p.S1712Y	DO41379	UCEC	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.0833
p.G637A	TCGA-AA-3666	COAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.25
p.G637A	DO9042	COAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.25
p.P2285T	TCGA-AA-A00N	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1944
p.P2285T	DO9876	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1944
p.T1763A	TCGA-AA-A010	COAD	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation altering degron motif	0.7139
p.T2318A	TCGA-AA-A010	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.0833
p.D1843N	TCGA-AG-4015	READ	TCGA	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.3056
p.D1843N	DO233765	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.3056
p.D1843N	DO36459	READ	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.3056
p.E1863K	TCGA-AG-A002	READ	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.E1863K	TCGA-D1-A17Q	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.E1863K	TCGA-ZF-AA4X	BLCA	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.E1863K	DO219091	BLCA	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.E1863K	DO41903	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.A2980S	TCGA-AG-A00Y	READ	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.3056
p.A2980S	DO36542	READ	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.3056
p.A2980D	TCGA-AG-A00Y	READ	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.3056
p.A2980D	DO36542	READ	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.3056
p.D1710Y	TCGA-AP-A051	UCEC	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.D1710Y	DO8730	COAD	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.D1710Y	DO42673	UCEC	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.F635L	TCGA-AP-A054	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1944
p.F635L	DO42256	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1944
p.G2189D	TCGA-AP-A056	UCEC	TCGA	NGLESYTTLP	CBL_PTK	2188:2197	Mutation altering degron motif	0.6087
p.G2189D	DO43971	UCEC	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation altering degron motif	0.6087
p.G1868D	TCGA-AP-A059	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.2778
p.G1868D	DO41361	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.2778
p.R63H	TCGA-AP-A0LM	UCEC	TCGA	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.R63H	TCGA-AP-A1DK	UCEC	TCGA	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.R63H	DO43306	UCEC	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.R63H	DO42033	UCEC	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.S2498N	TCGA-AX-A05Z	UCEC	TCGA	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2222
p.S2498N	DO40884	UCEC	ICGC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2222
p.S2329I	TCGA-AX-A06F	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation altering degron motif	0.7341
p.S2329I	DO41752	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation altering degron motif	0.7341
p.D2789Y	TCGA-AX-A1CE	UCEC	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.7325
p.D2789Y	DO42280	UCEC	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.7325
p.Q1040H	TCGA-AX-A2HC	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1111
p.Q1040H	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1111
p.K1057N	TCGA-AX-A2HC	UCEC	TCGA	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation substituting flanking lysine	0.3611
p.K1057N	TCGA-AX-A2HC	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation substituting flanking lysine	0.3056
p.K1057N	DO41572	UCEC	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation substituting flanking lysine	0.3611
p.K1057N	DO41572	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation substituting flanking lysine	0.3056
p.R63C	TCGA-AZ-4315	COAD	TCGA	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.R63C	DO8842	COAD	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.R63C	SIDM02039	Colorectal Carcinoma	GDSC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.L636F	TCGA-AZ-4315	COAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.2222
p.L636F	DO8842	COAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.2222
p.V3055I	TCGA-B5-A1MX	UCEC	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5965
p.V3055I	DO41999	UCEC	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5965
p.R898G	TCGA-B5-A3FC	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.0833
p.R898G	TCGA-B5-A3FC	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0556
p.R898G	DO41871	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.0833
p.R898G	DO41871	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0556
p.D1069N	TCGA-BF-A1PU	SKCM	TCGA	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.D1069N	TCGA-CV-6938	HNSC	TCGA	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.D1069N	TCGA-XF-A9SU	BLCA	TCGA	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.D1069N	DO223600	BLCA	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.D1069N	DO14462	HNSC	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.D1069N	DO50278	SKCM	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2222
p.M2304I	TCGA-BF-A1PU	SKCM	TCGA	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.0556
p.M2304I	DO50278	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.0556
p.M2788I	TCGA-BF-A1PZ	SKCM	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.3056
p.M2788I	DO50279	SKCM	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.3056
p.E1708K	TCGA-BF-AAP2	SKCM	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1944
p.E1708K	DO219466	SKCM	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1944
p.M2799T	TCGA-BH-A0EE	BRCA	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.3056
p.M2799T	TCGA-BH-A0EE	BRCA	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.1944
p.M2799T	DO6088	BRCA	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.3056
p.M2799T	DO6088	BRCA	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.1944
p.D1710N	TCGA-BR-4201	STAD	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.D1710N	DO38707	STAD	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.V1849G	TCGA-BS-A0UJ	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.3056
p.V1849G	DO42745	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.3056
p.S1547C	TCGA-C8-A12P	BRCA	TCGA	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2778
p.S1547C	DO4000	BRCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2778
p.S888T	TCGA-CC-A7IG	LIHC	TCGA	PTTST	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.6005
p.S888T	DO52179	LIHC	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.6005
p.E2494K	TCGA-CV-7568	HNSC	TCGA	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation altering degron motif	0.7022
p.E2494K	DO14160	HNSC	ICGC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation altering degron motif	0.7022
p.S895L	TCGA-CV-A6K2	HNSC	TCGA	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.S895L	DO52079	HNSC	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.P1844S	TCGA-D3-A8GR	SKCM	TCGA	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.6752
p.P1844S	DO51247	SKCM	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.6752
p.R650C	TCGA-D3-A8GS	SKCM	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.25
p.R650C	DO51248	SKCM	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.25
p.S2802T	TCGA-D5-6931	COAD	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2222
p.S2802T	TCGA-D5-6931	COAD	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.2778
p.S2802T	DO8384	COAD	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2222
p.S2802T	DO8384	COAD	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.2778
p.K431T	TCGA-D7-A4Z0	STAD	TCGA	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2778
p.K431T	DO47765	STAD	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2778
p.V3055L	TCGA-DD-AACA	LIHC	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5654
p.V3055L	DO52196	LIHC	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5654
p.P1872L	TCGA-DF-A2KU	UCEC	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.6471
p.P1872L	DO223286	UCEC	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.6471
p.P1872L	SIDM00957	Colorectal Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.6471
p.P1872L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.6471
p.P1872L	COLO-678	large intestine	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.6471
p.E652K	TCGA-DF-A2KV	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1944
p.E652K	DO219771	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1944
p.I1689V	TCGA-DK-A3IU	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1667
p.I1689V	DO612	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1667
p.D2797H	TCGA-DK-A6B5	BLCA	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.7688
p.D2797H	DO48551	BLCA	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation altering degron motif	0.7688
p.T2503A	TCGA-DM-A1DA	COAD	TCGA	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.0833
p.T2503A	DO7852	COAD	ICGC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.0833
p.D1766E	TCGA-DU-6392	LGG	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.3056
p.D1766E	DO22237	LGG	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.3056
p.E654K	TCGA-E6-A1LX	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.E654K	DO41020	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.E654K	KYM-1	soft tissue	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.E654K	GAK	skin	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.E654K	SNU-423	liver	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.E654K	MKN28	stomach	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1389
p.V2986I	TCGA-E6-A1LX	UCEC	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1389
p.V2986I	DO41020	UCEC	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1389
p.S3061F	TCGA-EB-A4IS	SKCM	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.7982
p.S3061F	TCGA-YD-A9TB	SKCM	TCGA	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.7982
p.S3061F	DO47281	SKCM	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.7982
p.S3061F	DO51297	SKCM	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.7982
p.G1730R	TCGA-EB-A85I	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.G1730R	DO50296	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.E1865K	TCGA-EE-A181	SKCM	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.E1865K	TCGA-QB-AA9O	SKCM	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.E1865K	DO37444	SKCM	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.E1865K	DO51267	SKCM	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.E2965K	TCGA-EE-A29M	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.0556
p.E2965K	DO37404	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.0556
p.S2977Y	TCGA-EE-A2GT	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation altering degron motif	0.712
p.S2977Y	DO37946	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation altering degron motif	0.712
p.D899Y	TCGA-EO-A22R	UCEC	TCGA	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.0556
p.D899Y	TCGA-EO-A22R	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0833
p.D899Y	DO42713	UCEC	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.0556
p.D899Y	DO42713	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0833
p.S2486L	TCGA-EO-A22X	UCEC	TCGA	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.25
p.S2486L	DO43907	UCEC	ICGC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.25
p.F1543L	TCGA-EO-A3B0	UCEC	TCGA	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6981
p.F1543L	DO219773	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6981
p.G922R	TCGA-ER-A198	SKCM	TCGA	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0556
p.G922R	DO47563	SKCM	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0556
p.K431N	TCGA-F5-6814	READ	TCGA	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2778
p.K431N	DO36556	READ	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2778
p.P1702L	TCGA-F5-6814	READ	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.7582
p.P1702L	DO36556	READ	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.7582
p.F1773V	TCGA-F5-6814	READ	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.F1773V	DO36556	READ	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.I1860S	TCGA-F5-6814	READ	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.0556
p.I1860S	DO36556	READ	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.0556
p.L2336V	TCGA-F5-6814	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.1944
p.L2336V	DO36556	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.1944
p.G2340A	TCGA-FD-A6TH	BLCA	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.0833
p.G2340A	DO49763	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.0833
p.T901I	TCGA-FG-A4MU	LGG	TCGA	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.1389
p.T901I	DO44558	LGG	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.1389
p.E921K	TCGA-FR-A69P	SKCM	TCGA	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0833
p.E921K	DO47292	SKCM	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.0833
p.T1734S	TCGA-FR-A7U9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.T1734S	DO48546	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.T1734M	TCGA-FR-A7U9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.T1734M	DO48546	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1667
p.P1753S	TCGA-GF-A6C9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.P1753S	TCGA-GF-A6C9	SKCM	TCGA	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.P1753S	DO51254	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.P1753S	DO51254	SKCM	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.N2496D	TCGA-HU-8602	STAD	TCGA	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2778
p.N2496D	DO47829	STAD	ICGC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2778
p.G2340E	TCGA-HZ-7926	PAAD	TCGA	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.0833
p.G2340E	DO32759	PAAD	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.0833
p.P2197T	TCGA-IB-7651	PAAD	TCGA	NGLESYTTLP	CBL_PTK	2188:2197	Mutation altering degron motif	0.7031
p.P2197T	DO46657	PAAD	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation altering degron motif	0.7031
p.I2782V	TCGA-IB-7651	PAAD	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.1389
p.I2782V	DO46657	PAAD	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.1389
p.F656L	TCGA-MI-A75C	LIHC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0833
p.F656L	DO49705	LIHC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0833
p.L2812S	TCGA-N7-A4Y0	UCS	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.1944
p.T2810S	TCGA-O2-A52Q	LUSC	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.25
p.T2810S	DO219219	LUSC	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.25
p.E1058K	TCGA-QB-A6FS	SKCM	TCGA	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2778
p.E1058K	TCGA-QB-A6FS	SKCM	TCGA	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1667
p.E1058K	DO48654	SKCM	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.2778
p.E1058K	DO48654	SKCM	ICGC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1667
p.N2803S	TCGA-S8-A6BW	ESCA	TCGA	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.1944
p.N2803S	TCGA-S8-A6BW	ESCA	TCGA	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.3056
p.L423S	TCGA-VQ-A8P5	STAD	TCGA	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.7667
p.L423S	DO51763	STAD	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.7667
p.S1747L	TCGA-VQ-A8PB	STAD	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.S1747L	DO233118	GACA	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.S1747L	DO229177	LMS	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.S1747L	DO51766	STAD	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.H1873R	TCGA-VQ-A924	STAD	TCGA	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.8244
p.H1873R	DO51795	STAD	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.8244
p.P2183S	TCGA-W3-AA1V	SKCM	TCGA	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.1944
p.P2183S	DO51276	SKCM	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.1944
p.P2183L	TCGA-W3-AA1V	SKCM	TCGA	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.1944
p.P2183L	DO51276	SKCM	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation rewiring degron network	0.1944
p.T1703A	TCGA-XF-A9SY	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.6028
p.T1703A	DO51918	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.6028
p.R2303K	TCGA-XF-A9T8	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.0833
p.R2303K	DO51927	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.0833
p.T1709K	TCGA-XF-AAMF	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1667
p.T1709K	DO51930	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1667
p.T1731P	TCGA-YD-A9TA	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.T1731P	DO219503	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0833
p.P2804L	TCGA-Z2-A8RT	SKCM	TCGA	PPYY	ITCH	2804:2807	Mutation altering degron motif	0.7582
p.P2804L	DO51301	SKCM	ICGC	PPYY	ITCH	2804:2807	Mutation altering degron motif	0.7582
p.P646L	TCGA-ZF-A9RL	BLCA	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.6471
p.P646L	DO219078	BLCA	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.6471
p.Q413K	DO48366	BLCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.0556
p.V1540F	DO219014	BLCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5957
p.Y1533D	DO538	BLCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1389
p.N57I	DO225228	BRCA	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.3056
p.V1548I	DO229340	BTCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.25
p.A1698T	DO52722	CLLE	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.7139
p.A1541T	DO10332	COAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.7139
p.G1543S	DO7825	COAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6993
p.G1543S	DO230607	PRAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6993
p.S911R	DO9940	COAD	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation altering degron motif	0.7427
p.D3070Y	DO230336	COCA	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.0833
p.F2301Y	DO230334	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229010	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229013	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229016	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229346	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229480	LAML	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO228941	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO228947	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO229047	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.F2301Y	DO230990	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.T48M	DO227657	COCA	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1944
p.T48M	SIDM02049	Pancreatic Carcinoma	GDSC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1944
p.T1534M	DO227996	COCA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1667
p.T1534M	PF-382	haematopoietic and lymphoid tissue	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1667
p.H2786L	DO52492	COCA	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.25
p.G428D	DO229005	COCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6087
p.G428D	DO229505	LAML	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6087
p.G428D	DO229047	LICA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6087
p.G428D	DO230550	LUSC	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6087
p.Q1695H	DO50408	ESAD	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation altering degron motif	0.647
p.A2971T	DO222570	ESCA	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.2222
p.V1706I	DO218774	GACA	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.25
p.C1535Y	DO233154	GACA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.S1050G	DO233760	GACA	ICGC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.6993
p.T3053A	DO233885	GACA	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.2778
p.A1053S	DO233951	GACA	ICGC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation rewiring degron network	0.1389
p.A1053S	DO233951	GACA	ICGC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.3056
p.K1536N	DO13863	GBM	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2222
p.K1536N	DO41379	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2222
p.K2202N	DO228948	LICA	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation substituting flanking lysine	0.3056
p.I1551T	DO228844	LICA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1667
p.A1762S	DO228971	LICA	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation altering degron motif	0.6477
p.L52M	DO232000	LICA	ICGC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.3056
p.A3056S	DO229031	LICA	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.6477
p.A892S	DO229041	LICA	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.25
p.G2970D	DO50970	LICA	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.P3059T	DO23551	LIRI	ICGC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.5919
p.Q884L	DO23516	LIRI	ICGC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.3056
p.P2804S	DO229249	LMS	ICGC	PPYY	ITCH	2804:2807	Mutation altering degron motif	0.6752
p.H2786Q	DO224563	LUSC	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.25
p.F1773C	DO220857	MELA	ICGC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.T2983I	DO220878	MELA	ICGC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.2222
p.S1853L	DO220901	MELA	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1944
p.P657S	DO220907	MELA	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0556
p.D2319H	DO222379	MELA	ICGC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.1111
p.G1549E	DO222494	MELA	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2222
p.G1730E	DO222632	MELA	ICGC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.0556
p.S911D	DO222743	MELA	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation altering degron motif	0.6871
p.D435N	DO222875	MELA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1667
p.P433F	DO222843	MELA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2222
p.M2799I	DO222843	MELA	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.3056
p.M2799I	DO222843	MELA	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.1944
p.E2191K	DO34448	PACA	ICGC	NGLESYTTLP	CBL_PTK	2188:2197	Mutation altering degron motif	0.591
p.V1856I	DO51507	PACA	ICGC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1111
p.V1856I	SIDM00217	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1111
p.V1856I	SNU-1040	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1111
p.E1865D	DO51493	PACA	ICGC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.A414V	DO228138	PBCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.0833
p.I909L	DO232869	PBCA	ICGC	PITST	DEG_SPOP_SBC_1	908:912	Mutation altering degron motif	0.6063
p.E1546K	DO36556	READ	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.3056
p.A1551S	DO220011	SARC	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1667
p.A1551S	DO41379	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1667
p.S2802F	DO219878	SKCA	ICGC	DQSVTEVPDV	DEG_COP1_1	2789:2798	Mutation rewiring degron network	0.2222
p.S2802F	DO219878	SKCA	ICGC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.2778
p.P1691S	DO228011	SKCA	ICGC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.2222
p.P433L	DO218908	SKCA	ICGC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.2222
p.G1555R	DO51761	STAD	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.0556
p.V1548L	DO40884	UCEC	ICGC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.25
p.E1535G	SIDM00697	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00395	Neuroblastoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00230	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00523	Small Cell Lung Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00782	Colorectal Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00094	Kidney Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00852	Glioma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM00701	Non-Cancerous	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.E1535G	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1944
p.S2504N	SIDM01169	Ovarian Carcinoma	GDSC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.0556
p.S2504N	ACH-000885	Ovarian Cancer	CCLE	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.0556
p.S2504N	TOV-21G	ovary	COSMIC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.0556
p.R630G	SIDM01090	Colorectal Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0556
p.R630G	ACH-000943	Colon/Colorectal Cancer	CCLE	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0556
p.R630G	RKO	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.0556
p.D1554N	SIDM01090	Colorectal Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.0833
p.D1554N	ACH-000943	Colon/Colorectal Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.0833
p.D1554N	RKO	large intestine	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.0833
p.T416A	SIDM00107	Melanoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.T416A	SIDM00282	Colorectal Carcinoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.T416A	ACH-000998	Colon/Colorectal Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.T416A	CW-2	large intestine	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.T416A	UACC-62	skin	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.L1854S	SIDM00602	Gastric Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1667
p.L1854S	ACH-000919	Gastric Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1667
p.L1854S	IM-95	stomach	COSMIC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation rewiring degron network	0.1667
p.P644L	SIDM00855	Other Sarcomas	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7582
p.P644L	SIDM00125	Kidney Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7582
p.P644L	SIDM01083	Oral Cavity Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7582
p.P1544S	SIDM00007	Other Solid Cancers	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5641
p.P1544S	ACH-001550	Skin Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5641
p.P1544S	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5641
p.P1544L	SIDM00007	Other Solid Cancers	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6471
p.P1544L	ACH-001550	Skin Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6471
p.P1544L	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.6471
p.F1773S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.F1773S	ACH-002256	Leukemia	CCLE	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.F1773S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1111
p.P1882Q	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.P1882Q	ACH-000860	Lung Cancer	CCLE	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.P1882Q	NCI-H358	lung	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1389
p.S1743A	SIDM00193	Colorectal Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7588
p.S1743A	ACH-000991	Colon/Colorectal Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7588
p.S1743A	SNU-81	large intestine	COSMIC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7588
p.H1873Q	SIDM00803	Kidney Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.7582
p.H1873Q	ACH-000411	Kidney Cancer	CCLE	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.7582
p.H1873Q	769-P	kidney	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation altering degron motif	0.7582
p.Q2973H	SIDM00155	Head and Neck Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.2778
p.Q2973H	PCI-38	upper aerodigestive tract	COSMIC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.2778
p.T1737I	SIDM00092	Ovarian Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.T1737I	ACH-000617	Ovarian Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.T1737I	OVCAR-4	ovary	COSMIC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.25
p.S2498I	SIDM01113	Other Sarcomas	GDSC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2222
p.S2498I	SK-UT-1	soft tissue	COSMIC	LPLHSE	LIG_APCC_ABBA_1	2489:2494	Mutation rewiring degron network	0.2222
p.L1063P	SIDM00871	Non-Cancerous	GDSC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation altering degron motif	0.6471
p.L1063P	SIDM00872	Breast Carcinoma	GDSC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation altering degron motif	0.6471
p.E1865G	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.E1865G	H3255	lung	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.1944
p.S1758G	SIDM00564	Ovarian Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.S1758G	ACH-000527	Ovarian Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.S1758G	OVISE	ovary	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.I415V	SIDM00493	Other Solid Cancers	GDSC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1111
p.T889I	SIDM00493	Other Solid Cancers	GDSC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.7078
p.E1545D	SIDM01052	Ovarian Carcinoma	GDSC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5647
p.E1545D	ACH-000308	Ovarian Cancer	CCLE	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5647
p.E1545D	EFO-21	ovary	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.5647
p.G1768D	SIDM00836	Colorectal Carcinoma	GDSC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.G1768D	ACH-000820	Colon/Colorectal Cancer	CCLE	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.G1768D	SW403	large intestine	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.M49I	SIDM00665	Gastric Carcinoma	GDSC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.2222
p.M49I	ACH-000616	Gastric Cancer	CCLE	PPSY	ITCH	53:56	Mutation rewiring degron network	0.2222
p.M49I	Hs746T	stomach	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.2222
p.Y56N	SIDM00217	Colorectal Carcinoma	GDSC	PPSY	ITCH	53:56	Mutation altering degron motif	0.7059
p.Y56N	SNU-1040	large intestine	COSMIC	PPSY	ITCH	53:56	Mutation altering degron motif	0.7059
p.E3050K	SIDM00217	Colorectal Carcinoma	GDSC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.1944
p.E3050K	ACH-000999	Colon/Colorectal Cancer	CCLE	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.1944
p.E3050K	SNU-1040	large intestine	COSMIC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation rewiring degron network	0.1944
p.G2970S	SIDM00045	Gastric Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.G2970S	ACH-002141	Gastric Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.G2970S	HSC-39	stomach	COSMIC	PHSTS	DEG_SPOP_SBC_1	2975:2979	Mutation rewiring degron network	0.1944
p.T2816P	SIDM00850	Gastric Carcinoma	GDSC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.0833
p.T2816P	ACH-000880	Gastric Cancer	CCLE	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.0833
p.T2816P	AGS	stomach	COSMIC	PPYY	ITCH	2804:2807	Mutation rewiring degron network	0.0833
p.V3055A	SIDM01059	Melanoma	GDSC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.6936
p.V3055A	ACH-000915	Skin Cancer	CCLE	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.6936
p.V3055A	IPC-298	skin	COSMIC	VATPPFS	DEG_SCF_FBW7_1	3055:3061	Mutation altering degron motif	0.6936
p.S895P	SIDM01140	Ovarian Carcinoma	GDSC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.S895P	ACH-001374	Ovarian Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.S895P	PA-1	ovary	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.T1847N	SIDM00359	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.7055
p.T1847N	ACH-000565	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.7055
p.T1847N	RCM-1	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.7055
p.E1043D	SIDM01611	Endometrial Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.E1043D	ACH-000996	Endometrial/Uterine Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.1944
p.T427A	SIDM01588	Endometrial Carcinoma	GDSC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6028
p.T427A	ACH-000993	Endometrial/Uterine Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation altering degron motif	0.6028
p.T880A	ACH-000586	Lung Cancer	CCLE	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1944
p.T880A	NCI-H1876	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1944
p.D634N	ACH-000881	Skin Cancer	CCLE	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1667
p.D634N	MEL-JUSO	skin	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1667
p.E1739D	ACH-000937	Leukemia	CCLE	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.3056
p.S415R	ACH-001081	Colon/Colorectal Cancer	CCLE	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1111
p.S415R	HCC2998	large intestine	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1111
p.V2292I	HCC1395	breast	COSMIC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation altering degron motif	0.7076
p.I1751M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation rewiring degron network	0.1389
p.I1751M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.0556
p.K1546Q	MCC13	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.3056
p.P895Q	NCI-H358	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation rewiring degron network	0.1667
p.V907D	HEL	haematopoietic and lymphoid tissue	COSMIC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.3056
p.V907D	CMK	haematopoietic and lymphoid tissue	COSMIC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.3056
p.G1741D	CP66-MEL	skin	COSMIC	VYSST	DEG_SPOP_SBC_1	1740:1744	Mutation altering degron motif	0.7198
p.E878G	H3255	lung	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation substituting flanking lysine	0.25
p.R638I	SNU-81	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.2778
p.S647Y	SNU-81	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.8231
p.G1847D	SK-UT-1	soft tissue	COSMIC	PETTT	DEG_SPOP_SBC_1	1844:1848	Mutation altering degron motif	0.7198
p.T917A	LS-411N	large intestine	COSMIC	PITST	DEG_SPOP_SBC_1	908:912	Mutation rewiring degron network	0.1944
p.S1869L	COLO-678	large intestine	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.3056
p.C2338R	AN3-CA	endometrium	COSMIC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.1389
p.F1554L	PC-3	prostate	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.0833
p.G63C	NCI-H650	lung	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1389
p.S655Y	CW-2	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1111
p.V62G	SNU-182	liver	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1667
p.V62G	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1667
p.V62G	SNU-81	large intestine	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.1667
p.V1061A	NCI-H748	lung	COSMIC	VTPLDE	DEG_SCF_FBW7_2	1060:1065	Mutation altering degron motif	0.6936
p.F2321L	PC-3	prostate	COSMIC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.1667
p.V418I	HOP-62	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1944
p.G51E	MEL-JUSO	skin	COSMIC	PPSY	ITCH	53:56	Mutation rewiring degron network	0.2778
p.T416I	RERF-LC-Sq1	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1389
p.G1541R	Hs939-T	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation altering degron motif	0.7568
p.R1038M	LoVo	large intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation substituting flanking lysine	0.1667
p.R1536C	COLO-792	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2222
p.A905V	LNCaP-Clone-FGC	prostate	COSMIC	PITST	DEG_SPOP_SBC_1	908:912	Mutation substituting flanking lysine	0.3611
p.P2293S	SW684	soft tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation altering degron motif	0.6752
p.P885L	COLO-678	large intestine	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.7582
p.K1547E	M14	skin	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.2778
p.P1553S	MFE-296	endometrium	COSMIC	VSLFPE	LIG_APCC_ABBA_1	1540:1545	Mutation rewiring degron network	0.1111
p.A1770T	NCI-H1155	lung	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.1944
p.G1048D	KM12	large intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation altering degron motif	0.7198
p.S2332F	IPC-298	skin	COSMIC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation rewiring degron network	0.3056
p.P1709S	Mewo	skin	COSMIC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1667
p.V430I	EFO-27	ovary	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.3056
p.R1710P	OAW-42	ovary	COSMIC	QPSAKVVPT	DEG_SIAH_1	1695:1703	Mutation rewiring degron network	0.1389
p.E634D	HT-115	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation rewiring degron network	0.1667
p.V1867I	RL95-2	endometrium	COSMIC	LSPHVE	LIG_APCC_ABBA_1	1870:1875	Mutation rewiring degron network	0.25
p.T2301M	PF-382	haematopoietic and lymphoid tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	2290:2294	Mutation rewiring degron network	0.1389
p.G645E	HCT-15	large intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	640:647	Mutation altering degron motif	0.7199
p.E437Q	NCI-H520	lung	COSMIC	LPTPTGS	DEG_SCF_FBW7_1	423:429	Mutation rewiring degron network	0.1111
p.H886Q	769-P	kidney	COSMIC	PTTST	DEG_SPOP_SBC_1	885:889	Mutation altering degron motif	0.7582
p.E1758K	HT-1376	urinary tract	COSMIC	VATSS	DEG_SPOP_SBC_1	1761:1765	Mutation rewiring degron network	0.25
p.R2327C	SNU-81	large intestine	COSMIC	VTSTT	DEG_SPOP_SBC_1	2327:2331	Mutation altering degron motif	0.8301
p.K1045T	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	ALSST	DEG_SPOP_SBC_1	1048:1052	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VCAN

UniProt ID: P13611

Entrez ID: 1462

Protein name: Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Glial hyaluronate-binding protein) (GHAP) (Large fibroblast proteoglycan) (PG-M)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VCAN in