DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 908:912

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 82.34

COIL: 0.7952

CONS_SCORE: 0.4301

DSS_SCORE: 0.5979

HELIX: 0.0162

FCONS_SCORE: 1.1319

RIG_SCORE: 0.7257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R898G	TCGA-B5-A3FC	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	0.0556
p.R898G	DO41871	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	0.0556
p.D899Y	TCGA-EO-A22R	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	0.0833
p.D899Y	DO42713	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	0.0833
p.G922R	TCGA-ER-A198	SKCM	TCGA	PITST	DEG_SPOP_SBC_1	0.0556
p.G922R	DO47563	SKCM	ICGC	PITST	DEG_SPOP_SBC_1	0.0556
p.T901I	TCGA-FG-A4MU	LGG	TCGA	PITST	DEG_SPOP_SBC_1	0.1389
p.T901I	DO44558	LGG	ICGC	PITST	DEG_SPOP_SBC_1	0.1389
p.E921K	TCGA-FR-A69P	SKCM	TCGA	PITST	DEG_SPOP_SBC_1	0.0833
p.E921K	DO47292	SKCM	ICGC	PITST	DEG_SPOP_SBC_1	0.0833
p.S911R	DO9940	COAD	ICGC	PITST	DEG_SPOP_SBC_1	0.7427
p.S911D	DO222743	MELA	ICGC	PITST	DEG_SPOP_SBC_1	0.6871
p.I909L	DO232869	PBCA	ICGC	PITST	DEG_SPOP_SBC_1	0.6063
p.V907D	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	PITST	DEG_SPOP_SBC_1	0.3056
p.V907D	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PITST	DEG_SPOP_SBC_1	0.3056
p.T917A	LS-411N	large_intestine	COSMIC	PITST	DEG_SPOP_SBC_1	0.1944
p.A905V	LNCaP-Clone-FGC	prostate	COSMIC	PITST	DEG_SPOP_SBC_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	908:912	PITST	SPOP	0.9967	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3787:3791	PITST	SPOP	0.5313	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SPOP_SBC_1	498:502	PITST	SPOP	0.9839	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	125:129	PITST	SPOP	0.9804	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	259:263	PITST	SPOP	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons