DegronMD - Q9BVL2(NUP58)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T445A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPFST	DEG_SCF_FBW7_1	452:457	Mutation blocking phosphorylation signal	0.5833
p.T445A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTPFST	DEG_SCF_FBW7_1	452:457	Mutation blocking phosphorylation signal	0.5833
p.T151I	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LTSTPAAS	DEG_SCF_FBW7_1	140:147	Mutation rewiring degron network	0.2222
p.T151I	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	ALTST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.T151I	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.0833
p.T151I	NCI-H1792	lung	COSMIC	LTSTPAAS	DEG_SCF_FBW7_1	140:147	Mutation rewiring degron network	0.2222
p.T151I	NCI-H1792	lung	COSMIC	ALTST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.T151I	NCI-H1792	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	160:164	Mutation rewiring degron network	0.0833
p.T106A	SIDM00177	Melanoma	GDSC	LGTPATT	DEG_SCF_FBW7_1	95:101	Mutation rewiring degron network	0.1944
p.T106A	SIDM00177	Melanoma	GDSC	PATTS	DEG_SPOP_SBC_1	98:102	Mutation rewiring degron network	0.2222
p.N460S	SIDM01611	Endometrial Carcinoma	GDSC	PTPFST	DEG_SCF_FBW7_1	452:457	Mutation rewiring degron network	0.25
p.T139I	NCI-H1792	lung	COSMIC	ALTST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7078

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons