DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGTPATT
Uniprot ID:
Q9BVL2
Source protein:
Nucleoporin p58/p45
Source gene:
NUP58
Class:
DEG_SCF_FBW7_1
Location:
95:101
E3 ligase:
FBXW7
DEGRON score:
0.9856
ASA_SCORE:
70.8
COIL:
0.8119
CONS_SCORE:
0.4132
DSS_SCORE:
0.3567
HELIX:
0.0301
FCONS_SCORE:
1.1393
RIG_SCORE:
0.787
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T106A
SIDM00177
Melanoma
GDSC
LGTPATT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with NUP58 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGTPATT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BVL2
Nucleoporin p58/p45
DEG_SCF_FBW7_1
95:101
LGTPATT
FBXW7
0.9856
More...