DegronMD

Uniprot ID: Q9BVL2

Source protein: Nucleoporin p58/p45

Source gene: NUP58

Class: DEG_SCF_FBW7_1

Location: 452:457

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 65.8833

COIL: 0.893

CONS_SCORE: 0.6291

DSS_SCORE: 0.58

HELIX: 0.0648

FCONS_SCORE: 1.47

RIG_SCORE: 0.6945

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T445A	SIDM00845	Burkitt's Lymphoma	GDSC	PTPFST	DEG_SCF_FBW7_1	0.5833
p.T445A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTPFST	DEG_SCF_FBW7_1	0.5833
p.N460S	SIDM01611	Endometrial Carcinoma	GDSC	PTPFST	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVL2	Nucleoporin p58/p45	DEG_SCF_FBW7_1	452:457	PTPFST	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons