DegronMD

Uniprot ID: Q9BVL2

Source protein: Nucleoporin p58/p45

Source gene: NUP58

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.9749

ASA_SCORE: 75.8

COIL: 0.8562

CONS_SCORE: 0.4199

DSS_SCORE: 0.3064

HELIX: 0.0798

FCONS_SCORE: 1.1087

RIG_SCORE: 0.7234

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T151I	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	ALTST	DEG_SPOP_SBC_1	0.1111
p.T151I	NCI-H1792	lung	COSMIC	ALTST	DEG_SPOP_SBC_1	0.1111
p.T139I	NCI-H1792	lung	COSMIC	ALTST	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	78:82	ALTST	SPOP	0.9355	More...
Q86UD0	Suppressor APC domain-containing protein 2	DEG_SPOP_SBC_1	326:330	ALTST	SPOP	0.9935	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	139:143	ALTST	SPOP	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons