DegronMD - Q14028(CNGB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T74N	TCGA-29-1770	OV	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.T74N	DO31664	OV	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.S81Y	TCGA-60-2698	LUSC	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.712
p.S81Y	DO26469	LUSC	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.712
p.E26K	TCGA-DA-A1IA	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.1389
p.E26K	DO38022	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.1389
p.G3S	TCGA-EB-A3Y6	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.0833
p.G3S	DO38081	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.0833
p.P12S	TCGA-EE-A3J5	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.6752
p.P12S	DO47331	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.6752
p.S70N	TCGA-EO-A22X	UCEC	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.S70N	DO43907	UCEC	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.A90T	TCGA-F6-A8O3	LGG	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.A90T	DO51823	LGG	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.A253V	TCGA-FI-A2D5	UCEC	TCGA	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1111
p.A253V	DO41331	UCEC	ICGC	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1111
p.K75N	TCGA-GN-A262	SKCM	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation substituting flanking lysine	0.3611
p.K75N	DO37515	SKCM	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation substituting flanking lysine	0.3611
p.P69S	TCGA-IB-7651	PAAD	TCGA	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0833
p.P69S	DO46657	PAAD	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.0833
p.Q6H	TCGA-IG-A5B8	ESCA	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.1667
p.T74S	DO222412	BTCA	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.A87T	DO234282	ESAD	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1944
p.R17Q	DO228607	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.6218
p.R17W	DO233154	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.7523
p.R7S	DO233652	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.1944
p.G238S	DO49691	LIAD	ICGC	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.T82S	DO228574	LICA	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.6005
p.E24K	DO231067	LUSC	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.1944
p.S84F	DO220899	MELA	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.S84F	DO229470	SKCA	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2778
p.V8G	DO219879	SKCA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation rewiring degron network	0.2222
p.R86Q	DO228012	SKCA	ICGC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.2222
p.A241S	DO229218	THCA	ICGC	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.7588
p.G238D	SIDM00466	Ovarian Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.25
p.A241T	SIDM00793	Burkitt's Lymphoma	GDSC	AQTSS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.7139
p.P16A	SIDM01609	Endometrial Carcinoma	GDSC	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.7503
p.P16A	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPGTPRKT	DEG_SCF_FBW7_1	12:19	Mutation altering degron motif	0.7503
p.A78T	SIDM01765	Osteosarcoma	GDSC	ALTST	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7139

Kaplan plot for CNGB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNGB1

UniProt ID: Q14028

Entrez ID: 1258

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNGB1 in