DegronMD

Uniprot ID: Q14028

Source protein: Cyclic nucleotide-gated cation channel beta-1

Source gene: CNGB1

Class: DEG_SPOP_SBC_1

Location: 78:82

E3 ligase: SPOP

DEGRON score: 0.9355

ASA_SCORE: 71.44

COIL: 0.693

CONS_SCORE: 0.3939

DSS_SCORE: 0.5665

HELIX: 0.2564

FCONS_SCORE: 0.9998

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T74N	TCGA-29-1770	OV	TCGA	ALTST	DEG_SPOP_SBC_1	0.2222
p.T74N	DO31664	OV	ICGC	ALTST	DEG_SPOP_SBC_1	0.2222
p.S81Y	TCGA-60-2698	LUSC	TCGA	ALTST	DEG_SPOP_SBC_1	0.712
p.S81Y	DO26469	LUSC	ICGC	ALTST	DEG_SPOP_SBC_1	0.712
p.S70N	TCGA-EO-A22X	UCEC	TCGA	ALTST	DEG_SPOP_SBC_1	0.1111
p.S70N	DO43907	UCEC	ICGC	ALTST	DEG_SPOP_SBC_1	0.1111
p.A90T	TCGA-F6-A8O3	LGG	TCGA	ALTST	DEG_SPOP_SBC_1	0.1111
p.A90T	DO51823	LGG	ICGC	ALTST	DEG_SPOP_SBC_1	0.1111
p.K75N	TCGA-GN-A262	SKCM	TCGA	ALTST	DEG_SPOP_SBC_1	0.3611
p.K75N	DO37515	SKCM	ICGC	ALTST	DEG_SPOP_SBC_1	0.3611
p.P69S	TCGA-IB-7651	PAAD	TCGA	ALTST	DEG_SPOP_SBC_1	0.0833
p.P69S	DO46657	PAAD	ICGC	ALTST	DEG_SPOP_SBC_1	0.0833
p.T74S	DO222412	BTCA	ICGC	ALTST	DEG_SPOP_SBC_1	0.2222
p.A87T	DO234282	ESAD	ICGC	ALTST	DEG_SPOP_SBC_1	0.1944
p.T82S	DO228574	LICA	ICGC	ALTST	DEG_SPOP_SBC_1	0.6005
p.S84F	DO220899	MELA	ICGC	ALTST	DEG_SPOP_SBC_1	0.2778
p.S84F	DO229470	SKCA	ICGC	ALTST	DEG_SPOP_SBC_1	0.2778
p.R86Q	DO228012	SKCA	ICGC	ALTST	DEG_SPOP_SBC_1	0.2222
p.A78T	SIDM01765	Osteosarcoma	GDSC	ALTST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	78:82	ALTST	SPOP	0.9355	More...
Q86UD0	Suppressor APC domain-containing protein 2	DEG_SPOP_SBC_1	326:330	ALTST	SPOP	0.9935	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	139:143	ALTST	SPOP	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons