DegronMD

Uniprot ID: Q86UD0

Source protein: Suppressor APC domain-containing protein 2

Source gene: SAPCD2

Class: DEG_SPOP_SBC_1

Location: 326:330

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 79.74

COIL: 0.9138

CONS_SCORE: 0.2102

DSS_SCORE: 0.5522

HELIX: 0.0644

FCONS_SCORE: 0.6887

RIG_SCORE: 0.6364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q338L	TCGA-2Y-A9HB	LIHC	TCGA	ALTST	DEG_SPOP_SBC_1	0.1111
p.Q338L	DO219541	LIHC	ICGC	ALTST	DEG_SPOP_SBC_1	0.1111
p.T328M	TCGA-OR-A5LT	ACC	TCGA	ALTST	DEG_SPOP_SBC_1	0.7423
p.Q338H	DO34873	PACA	ICGC	ALTST	DEG_SPOP_SBC_1	0.1111
p.T330A	ACH-000937	Leukemia	CCLE	ALTST	DEG_SPOP_SBC_1	0.7139
p.P333L	ACH-002019	Cervical Cancer	CCLE	ALTST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	78:82	ALTST	SPOP	0.9355	More...
Q86UD0	Suppressor APC domain-containing protein 2	DEG_SPOP_SBC_1	326:330	ALTST	SPOP	0.9935	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	139:143	ALTST	SPOP	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons