DegronMD

Uniprot ID: Q14028

Source protein: Cyclic nucleotide-gated cation channel beta-1

Source gene: CNGB1

Class: DEG_SCF_FBW7_1

Location: 12:19

E3 ligase: FBXW7

DEGRON score: 0.8098

ASA_SCORE: 84.9375

COIL: 0.9173

CONS_SCORE: 0.4046

DSS_SCORE: 0.7117

HELIX: 0.0558

FCONS_SCORE: 1.0267

RIG_SCORE: 0.5796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E26K	TCGA-DA-A1IA	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	0.1389
p.E26K	DO38022	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.1389
p.G3S	TCGA-EB-A3Y6	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	0.0833
p.G3S	DO38081	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.0833
p.P12S	TCGA-EE-A3J5	SKCM	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	0.6752
p.P12S	DO47331	SKCM	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.6752
p.Q6H	TCGA-IG-A5B8	ESCA	TCGA	PPGTPRKT	DEG_SCF_FBW7_1	0.1667
p.R17Q	DO228607	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.6218
p.R17W	DO233154	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.7523
p.R7S	DO233652	GACA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.1944
p.E24K	DO231067	LUSC	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.1944
p.V8G	DO219879	SKCA	ICGC	PPGTPRKT	DEG_SCF_FBW7_1	0.2222
p.P16A	SIDM01609	Endometrial Carcinoma	GDSC	PPGTPRKT	DEG_SCF_FBW7_1	0.7503
p.P16A	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPGTPRKT	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SCF_FBW7_1	12:19	PPGTPRKT	FBXW7	0.8098	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons