DegronMD

Uniprot ID: Q14028

Source protein: Cyclic nucleotide-gated cation channel beta-1

Source gene: CNGB1

Class: DEG_SPOP_SBC_1

Location: 241:245

E3 ligase: SPOP

DEGRON score: 0.9093

ASA_SCORE: 76.84

COIL: 0.7728

CONS_SCORE: 0.411

DSS_SCORE: 0.8658

HELIX: 0.035

FCONS_SCORE: 1.0288

RIG_SCORE: 0.5691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A253V	TCGA-FI-A2D5	UCEC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1111
p.A253V	DO41331	UCEC	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1111
p.G238S	DO49691	LIAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.25
p.A241S	DO229218	THCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7588
p.G238D	SIDM00466	Ovarian Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.25
p.A241T	SIDM00793	Burkitt's Lymphoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55283	Cadherin-4	DEG_SPOP_SBC_1	122:126	AQTSS	SPOP	0.6933	More...
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	241:245	AQTSS	SPOP	0.9093	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10774:10778	AQTSS	SPOP	0.5997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons