DegronMD

Uniprot ID: P55283

Source protein: Cadherin-4

Source gene: CDH4

Class: DEG_SPOP_SBC_1

Location: 122:126

E3 ligase: SPOP

DEGRON score: 0.6933

ASA_SCORE: 64.5

COIL: 0.621

CONS_SCORE: 0.4037

DSS_SCORE: 0.478

HELIX: 0.015

FCONS_SCORE: 0.9444

RIG_SCORE: 0.6642

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P133L	TCGA-06-5416	GBM	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1389
p.P133L	TCGA-95-7043	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1389
p.H131N	TCGA-33-4566	LUSC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1944
p.A115S	TCGA-55-8615	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1389
p.H128Y	TCGA-62-8402	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.2778
p.W113L	TCGA-94-A5I4	LUSC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.0833
p.R118Q	TCGA-AF-6136	READ	TCGA	AQTSS	DEG_SPOP_SBC_1	0.2222
p.Q123R	TCGA-CK-6746	COAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.6218
p.G136R	TCGA-QC-A7B5	SARC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.0556
p.G136E	TCGA-QC-A7B5	SARC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.0556
p.Y131H	DO217887	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1944
p.S121Y	DO2425	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.3056
p.R130W	DO4677	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.R130W	DO10340	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.R130W	DO7776	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.R130W	SNU-1040	large_intestine	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.R120Q	DO229381	BTCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2778
p.P113L	DO8192	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.0833
p.P113L	DO47401	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	0.0833
p.R130Q	DO7780	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.R130Q	DO22111	LGG	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.T134M	DO222789	ESCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1111
p.Q115K	DO228907	LICA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1389
p.R120W	DO32267	OV	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2778
p.P113S	DO37406	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	0.0833
p.S125W	SIDM00948	Burkitt's Lymphoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.7874
p.S125W	SIDM01398	Melanoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.7874
p.S125W	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.7874
p.A115T	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.1389
p.A115T	NCI-H2342	lung	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.1389
p.W113C	SIDM01664	Prostate Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.0833
p.W113C	ACH-000952	Prostate Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	0.0833
p.V116L	ACH-000790	Lung Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	0.1667
p.K123R	HEC-1	endometrium	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.7237
p.P128L	NCI-H720	lung	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.2778
p.D122N	RVH-421	skin	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.6932
p.S132F	SW684	soft_tissue	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55283	Cadherin-4	DEG_SPOP_SBC_1	122:126	AQTSS	SPOP	0.6933	More...
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	241:245	AQTSS	SPOP	0.9093	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10774:10778	AQTSS	SPOP	0.5997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQTSS

Degron related mutations and impact score

Drug responses associated with CDH4 mutations

All proteins holding degron of AQTSS