DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10774:10778

E3 ligase: SPOP

DEGRON score: 0.5997

ASA_SCORE: 92.02

COIL: 0.8752

CONS_SCORE: 0

DSS_SCORE: 0.48

HELIX: 0.0244

FCONS_SCORE: 0

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S10777C	TCGA-43-8116	LUSC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.7541
p.S10777C	DO27349	LUSC	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7541
p.S10786L	TCGA-AA-3977	COAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.1111
p.S10786L	DO8730	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1111
p.S10786L	DO222818	MELA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.1111
p.S10778L	TCGA-AA-A00N	COAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	TCGA-DM-A285	COAD	TCGA	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	TCGA-EE-A181	SKCM	TCGA	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	DO9490	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	DO9876	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	DO220906	MELA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7667
p.S10778L	DO37444	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7667
p.P10772L	TCGA-D3-A8GO	SKCM	TCGA	AQTSS	DEG_SPOP_SBC_1	0.2778
p.P10772L	DO51242	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2778
p.A10774T	TCGA-E6-A1LX	UCEC	TCGA	AQTSS	DEG_SPOP_SBC_1	0.7139
p.A10774T	DO41020	UCEC	ICGC	AQTSS	DEG_SPOP_SBC_1	0.7139
p.A10774T	SIDM00150	Colorectal Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.7139
p.A10774T	ACH-000969	Colon/Colorectal Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	0.7139
p.A10774T	KM12	large_intestine	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.7139
p.T10782S	TCGA-FR-A8YC	SKCM	TCGA	AQTSS	DEG_SPOP_SBC_1	0.2222
p.T10782S	DO50301	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	0.2222
p.T10764M	DO223138	ESCA	ICGC	AQTSS	DEG_SPOP_SBC_1	0.0556
p.L10768F	SIDM00562	Breast Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	0.1667
p.L10768F	ACH-002163	Breast Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	0.1667
p.L10768F	MRK-nu-1	breast	COSMIC	AQTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55283	Cadherin-4	DEG_SPOP_SBC_1	122:126	AQTSS	SPOP	0.6933	More...
Q14028	Cyclic nucleotide-gated cation channel beta-1	DEG_SPOP_SBC_1	241:245	AQTSS	SPOP	0.9093	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10774:10778	AQTSS	SPOP	0.5997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons