DegronMD - P55283(CDH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P133L	TCGA-06-5416	GBM	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.P133L	TCGA-95-7043	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.H131N	TCGA-33-4566	LUSC	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.A115S	TCGA-55-8615	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.H128Y	TCGA-62-8402	LUAD	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.W113L	TCGA-94-A5I4	LUSC	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.R118Q	TCGA-AF-6136	READ	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.Q123R	TCGA-CK-6746	COAD	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6218
p.G136R	TCGA-QC-A7B5	SARC	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.G136E	TCGA-QC-A7B5	SARC	TCGA	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0556
p.Y131H	DO217887	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944
p.S121Y	DO2425	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.3056
p.R130W	DO4677	BRCA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130W	DO10340	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130W	DO7776	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130W	SNU-1040	large intestine	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R120Q	DO229381	BTCA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.P113L	DO8192	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.P113L	DO47401	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.R130Q	DO7780	COAD	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.R130Q	DO22111	LGG	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2222
p.T134M	DO222789	ESCA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1111
p.Q115K	DO228907	LICA	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.R120W	DO32267	OV	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.P113S	DO37406	SKCM	ICGC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.S125W	SIDM00948	Burkitt's Lymphoma	GDSC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7874
p.S125W	SIDM01398	Melanoma	GDSC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7874
p.S125W	DG-75	haematopoietic and lymphoid tissue	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7874
p.A115T	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.A115T	NCI-H2342	lung	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.W113C	SIDM01664	Prostate Carcinoma	GDSC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.W113C	ACH-000952	Prostate Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.0833
p.V116L	ACH-000790	Lung Cancer	CCLE	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1667
p.K123R	HEC-1	endometrium	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.7237
p.P128L	NCI-H720	lung	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.2778
p.D122N	RVH-421	skin	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.6932
p.S132F	SW684	soft tissue	COSMIC	AQTSS	DEG_SPOP_SBC_1	122:126	Mutation substituting flanking lysine	0.2778

Kaplan plot for CDH4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH4

UniProt ID: P55283

Entrez ID: 1002

Protein name: Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH4 in