DegronMD - Q5JSP0(FGD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G18E	TCGA-63-7023	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1667
p.G18E	DO26494	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1667
p.G38R	TCGA-85-8666	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.0556
p.G38R	DO45547	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.0556
p.S26I	TCGA-A7-A0DA	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.7341
p.S26I	DO5870	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.7341
p.P498H	TCGA-AP-A059	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7694
p.P498H	DO41361	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7694
p.E512K	TCGA-AP-A1DV	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.E512K	TCGA-D1-A17Q	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.E512K	DO43186	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.E512K	DO41903	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.S136Y	TCGA-B5-A1MX	UCEC	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation altering degron motif	0.712
p.S136Y	DO41999	UCEC	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation altering degron motif	0.712
p.G18W	TCGA-BR-4363	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1667
p.G18W	DO38815	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1667
p.G25D	TCGA-BR-4368	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.6087
p.G25D	DO38715	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation altering degron motif	0.6087
p.T139A	TCGA-BR-8360	STAD	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation altering degron motif	0.825
p.T139A	DO47745	STAD	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation altering degron motif	0.825
p.G131V	TCGA-CR-7364	HNSC	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2222
p.G131V	DO15679	HNSC	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2222
p.P36S	TCGA-DD-A4NK	LIHC	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1111
p.P36S	DO44882	LIHC	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1111
p.P36T	TCGA-DZ-6133	KIRP	TCGA	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1111
p.P36T	DO20762	KIRP	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1111
p.E133K	TCGA-EE-A3J5	SKCM	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2778
p.E133K	DO222714	MELA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2778
p.E133K	DO47331	SKCM	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2778
p.E489K	TCGA-GV-A6ZA	BLCA	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.E489K	DO49776	BLCA	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.T500M	TCGA-HU-8602	STAD	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7423
p.T500M	DO47829	STAD	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7423
p.T510A	TCGA-P4-AAVM	KIRP	TCGA	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.T510A	DO219695	KIRP	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.T510A	ACH-002059	Leukemia	CCLE	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.T510A	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.A150S	DO222574	BTCA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.1111
p.T511I	DO233784	GACA	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.V508E	DO228422	LICA	ICGC	PITST	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.D129Y	DO228978	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.1667
p.V37F	DO229028	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.0833
p.A143S	DO229024	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.3056
p.D127E	DO50766	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.1111
p.LP35LS	DO222708	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0
p.D146N	DO222837	MELA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.2222
p.L35I	DO232858	NACA	ICGC	PGSSS	DEG_SPOP_SBC_1	24:28	Mutation rewiring degron network	0.1389
p.R74Q	DO221541	PACA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.G77E	DO229494	SKCA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation altering degron motif	0.7199
p.A126V	SIDM01943	Colorectal Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.A126V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.A126V	SIDM01617	Endometrial Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.A126V	ACH-000953	Leukemia	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.A126V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.A126V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.0833
p.S66R	SIDM02033	Colorectal Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.0833
p.A86T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.1667
p.A86T	ACH-002256	Leukemia	CCLE	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.1667
p.A86T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.1667
p.P81S	SIDM00146	Breast Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.P81S	ACH-000768	Breast Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.P81S	MDA-MB-231	breast	COSMIC	DSGIDS	DEG_SCF_TRCP1_1	75:80	Mutation rewiring degron network	0.3056
p.E132D	SIDM01449	Pancreatic Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.25
p.E132D	ACH-000517	Pancreatic Cancer	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	135:142	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGD3

UniProt ID: Q5JSP0

Entrez ID: 89846

Protein name: FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGD3 in