DegronMD

Uniprot ID: Q5JSP0

Source protein: FYVE, RhoGEF and PH domain-containing protein 3

Source gene: FGD3

Class: DEG_SCF_TRCP1_1

Location: 75:80

E3 ligase: BTRC

DEGRON score: 0.9985

ASA_SCORE: 67.15

COIL: 0.917

CONS_SCORE: 0.3386

DSS_SCORE: 0.6155

HELIX: 0.0462

FCONS_SCORE: 1.044

RIG_SCORE: 0.5955

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G77E	DO229494	SKCA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.7199
p.R74Q	DO221541	PACA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.P81S	SIDM00146	Breast Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.P81S	ACH-000768	Breast Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.P81S	MDA-MB-231	breast	COSMIC	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.A86T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.1667
p.A86T	ACH-002256	Leukemia	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.1667
p.A86T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIDS	DEG_SCF_TRCP1_1	0.1667
p.S66R	SIDM02033	Colorectal Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.0833

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	DEG_SCF_TRCP1_1	282:287	DSGIDS	BTRC	0.995	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SCF_TRCP1_1	75:80	DSGIDS	BTRC	0.9985	More...
Q6ZVD7	Storkhead-box protein 1	DEG_SCF_TRCP1_1	934:939	DSGIDS	BTRC	0.974	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons