DegronMD - P98174(FGD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P279S	TCGA-24-1551	OV	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.25
p.P279S	DO30920	OV	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.25
p.R273L	TCGA-2Y-A9GT	LIHC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.R273L	DO219506	LIHC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.V718L	TCGA-34-8454	LUSC	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1389
p.V718L	DO50094	LUSC	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1389
p.R134C	TCGA-85-A4CL	LUSC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.R134C	DO45454	LUSC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.R134C	SIDM00353	Other Sarcomas	GDSC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.R134C	ACH-000505	Sarcoma	CCLE	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.R134C	RKN	ovary	COSMIC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.E296D	TCGA-A5-A1OF	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.E296D	TCGA-B5-A0JY	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.E296D	DO43041	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.E296D	DO42568	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.E295D	TCGA-A5-A1OF	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1111
p.E295D	DO42568	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1111
p.S114R	TCGA-AX-A2HC	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation blocking phosphorylation signal	0.5278
p.S114R	DO41572	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation blocking phosphorylation signal	0.5278
p.G120V	TCGA-B5-A0JY	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.25
p.G120V	DO43041	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.25
p.T726M	TCGA-B5-A3FA	UCEC	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation altering degron motif	0.8534
p.T726M	TCGA-S9-A7IZ	LGG	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation altering degron motif	0.8534
p.T726M	DO50207	LGG	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation altering degron motif	0.8534
p.T726M	DO52402	UCEC	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation altering degron motif	0.8534
p.R132W	TCGA-BG-A222	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.R132W	TCGA-BR-A4J5	STAD	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.R132W	DO38185	STAD	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.R132W	DO42977	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.R134S	TCGA-BT-A20U	BLCA	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.R134S	DO538	BLCA	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1667
p.S715F	TCGA-CV-6003	HNSC	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation blocking phosphorylation signal	0.5
p.S715F	DO15639	HNSC	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation blocking phosphorylation signal	0.5
p.P130L	TCGA-CV-7415	HNSC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2778
p.P130L	DO14926	HNSC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2778
p.R738C	TCGA-D1-A167	UCEC	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R738C	DO228138	PBCA	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R738C	DO40978	UCEC	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R738C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R738C	ACH-001127	Leukemia	CCLE	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R738C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.1111
p.R723W	TCGA-DW-7836	KIRP	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.R723W	DO20847	KIRP	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.D609Y	TCGA-EE-A184	SKCM	TCGA	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.25
p.D609Y	DO47442	SKCM	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.25
p.D118N	TCGA-EK-A3GK	CESC	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1944
p.D118N	DO49964	CESC	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1944
p.R610Q	TCGA-EO-A22U	UCEC	TCGA	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.2778
p.R610Q	DO43755	UCEC	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.2778
p.R723L	TCGA-ET-A39R	THCA	TCGA	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.R723L	DO39552	THCA	ICGC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.R723L	ACH-002027	Endometrial/Uterine Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.P624S	TCGA-EY-A549	UCEC	TCGA	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.1389
p.P624S	DO48174	UCEC	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.1389
p.R132L	TCGA-FY-A76V	THCA	TCGA	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.R132L	DO51459	THCA	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.G284S	TCGA-HU-A4GU	STAD	TCGA	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation altering degron motif	0.6993
p.G284S	DO47849	STAD	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation altering degron motif	0.6993
p.R618S	TCGA-YY-A8LH	PAAD	TCGA	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.3056
p.R618S	DO50273	PAAD	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.3056
p.V623M	DO222991	BTCA	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.1667
p.V623M	DO233200	GACA	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.1667
p.V623M	SIDM01413	Oral Cavity Carcinoma	GDSC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.1667
p.D274E	DO233780	GACA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1111
p.D136E	DO229015	LICA	ICGC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.1111
p.Q608K	DO229029	LICA	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.2222
p.D609E	DO229022	LICA	ICGC	LILFND	LIG_APCC_ABBA_1	612:617	Mutation rewiring degron network	0.25
p.R273W	SIDM00659	Glioblastoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.R273W	ACH-000152	Brain Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.R273W	ACH-001118	Brain Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.0833
p.G275S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1389
p.G275S	ACH-002059	Leukemia	CCLE	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1389
p.R132Q	SIDM01170	Ovarian Carcinoma	GDSC	LEPHPE	LIG_APCC_ABBA_1	123:128	Mutation rewiring degron network	0.2222
p.E295Q	SIDM00528	Breast Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1111
p.E295Q	ACH-000934	Breast Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	282:287	Mutation rewiring degron network	0.1111
p.R723Q	SIDM01770	Gastric Carcinoma	GDSC	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.R723Q	ACH-000908	Gastric Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.2778
p.P716A	ACH-002039	Pancreatic Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	725:730	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGD1

UniProt ID: P98174

Entrez ID: 2245

Protein name: FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGD1 in