DegronMD

Uniprot ID: P98174

Source protein: FYVE, RhoGEF and PH domain-containing protein 1

Source gene: FGD1

Class: LIG_APCC_ABBA_1

Location: 123:128

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9835

ASA_SCORE: 97.9833

COIL: 0.9518

CONS_SCORE: 0.3275

DSS_SCORE: 0.8588

HELIX: 0.0163

FCONS_SCORE: 0.9974

RIG_SCORE: 0.5319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R134C	TCGA-85-A4CL	LUSC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.R134C	DO45454	LUSC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.R134C	SIDM00353	Other Sarcomas	GDSC	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.R134C	ACH-000505	Sarcoma	CCLE	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.R134C	RKN	ovary	COSMIC	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.S114R	TCGA-AX-A2HC	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.5278
p.S114R	DO41572	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.5278
p.G120V	TCGA-B5-A0JY	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.25
p.G120V	DO43041	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.25
p.R132W	TCGA-BG-A222	UCEC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.R132W	TCGA-BR-A4J5	STAD	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.R132W	DO38185	STAD	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.R132W	DO42977	UCEC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.R134S	TCGA-BT-A20U	BLCA	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.R134S	DO538	BLCA	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.1667
p.P130L	TCGA-CV-7415	HNSC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.2778
p.P130L	DO14926	HNSC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.2778
p.D118N	TCGA-EK-A3GK	CESC	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.1944
p.D118N	DO49964	CESC	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.1944
p.R132L	TCGA-FY-A76V	THCA	TCGA	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.R132L	DO51459	THCA	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.2222
p.D136E	DO229015	LICA	ICGC	LEPHPE	LIG_APCC_ABBA_1	0.1111
p.R132Q	SIDM01170	Ovarian Carcinoma	GDSC	LEPHPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	LIG_APCC_ABBA_1	123:128	LEPHPE	APC,CDC20,FZR1	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons