DegronMD

Uniprot ID: P98174

Source protein: FYVE, RhoGEF and PH domain-containing protein 1

Source gene: FGD1

Class: DEG_SCF_TRCP1_1

Location: 282:287

E3 ligase: BTRC

DEGRON score: 0.995

ASA_SCORE: 67.0667

COIL: 0.8517

CONS_SCORE: 0.3928

DSS_SCORE: 0.6896

HELIX: 0.0463

FCONS_SCORE: 1.2105

RIG_SCORE: 0.6361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P279S	TCGA-24-1551	OV	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.25
p.P279S	DO30920	OV	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.25
p.R273L	TCGA-2Y-A9GT	LIHC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.R273L	DO219506	LIHC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.E296D	TCGA-A5-A1OF	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.E296D	TCGA-B5-A0JY	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.E296D	DO43041	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.E296D	DO42568	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.E295D	TCGA-A5-A1OF	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.1111
p.E295D	DO42568	UCEC	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.1111
p.G284S	TCGA-HU-A4GU	STAD	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.6993
p.G284S	DO47849	STAD	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.6993
p.D274E	DO233780	GACA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.1111
p.R273W	SIDM00659	Glioblastoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.R273W	ACH-000152	Brain Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.R273W	ACH-001118	Brain Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.0833
p.G275S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.1389
p.G275S	ACH-002059	Leukemia	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.1389
p.E295Q	SIDM00528	Breast Carcinoma	GDSC	DSGIDS	DEG_SCF_TRCP1_1	0.1111
p.E295Q	ACH-000934	Breast Cancer	CCLE	DSGIDS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	DEG_SCF_TRCP1_1	282:287	DSGIDS	BTRC	0.995	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SCF_TRCP1_1	75:80	DSGIDS	BTRC	0.9985	More...
Q6ZVD7	Storkhead-box protein 1	DEG_SCF_TRCP1_1	934:939	DSGIDS	BTRC	0.974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons