DegronMD

Uniprot ID: Q6ZVD7

Source protein: Storkhead-box protein 1

Source gene: STOX1

Class: DEG_SCF_TRCP1_1

Location: 934:939

E3 ligase: BTRC

DEGRON score: 0.974

ASA_SCORE: 66.3333

COIL: 0.8917

CONS_SCORE: 0.4698

DSS_SCORE: 0.6815

HELIX: 0.0557

FCONS_SCORE: 1.2217

RIG_SCORE: 0.6085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R941Q	TCGA-B5-A11E	UCEC	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.2778
p.D938Y	TCGA-DU-6392	LGG	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.6214
p.E927Q	TCGA-E2-A10C	BRCA	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.1389
p.E927Q	DO1334	BRCA	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.1389
p.G946R	TCGA-EI-6507	READ	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.1389
p.P940T	TCGA-FS-A1ZQ	SKCM	TCGA	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.P940T	DO37442	SKCM	ICGC	DSGIDS	DEG_SCF_TRCP1_1	0.3056
p.G935V	NCI-H2029	lung	COSMIC	DSGIDS	DEG_SCF_TRCP1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	DEG_SCF_TRCP1_1	282:287	DSGIDS	BTRC	0.995	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SCF_TRCP1_1	75:80	DSGIDS	BTRC	0.9985	More...
Q6ZVD7	Storkhead-box protein 1	DEG_SCF_TRCP1_1	934:939	DSGIDS	BTRC	0.974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons