DegronMD

Uniprot ID: P98174

Source protein: FYVE, RhoGEF and PH domain-containing protein 1

Source gene: FGD1

Class: DEG_SCF_FBW7_2

Location: 725:730

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 86.9

COIL: 0.788

CONS_SCORE: 0.3049

DSS_SCORE: 0.4188

HELIX: 0.1573

FCONS_SCORE: 1.0006

RIG_SCORE: 0.7132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V718L	TCGA-34-8454	LUSC	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.1389
p.V718L	DO50094	LUSC	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.1389
p.T726M	TCGA-B5-A3FA	UCEC	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.8534
p.T726M	TCGA-S9-A7IZ	LGG	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.8534
p.T726M	DO50207	LGG	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.8534
p.T726M	DO52402	UCEC	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.8534
p.S715F	TCGA-CV-6003	HNSC	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.5
p.S715F	DO15639	HNSC	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.5
p.R738C	TCGA-D1-A167	UCEC	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R738C	DO228138	PBCA	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R738C	DO40978	UCEC	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R738C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R738C	ACH-001127	Leukemia	CCLE	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R738C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPIRE	DEG_SCF_FBW7_2	0.1111
p.R723W	TCGA-DW-7836	KIRP	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723W	DO20847	KIRP	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723L	TCGA-ET-A39R	THCA	TCGA	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723L	DO39552	THCA	ICGC	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723L	ACH-002027	Endometrial/Uterine Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723Q	SIDM01770	Gastric Carcinoma	GDSC	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.R723Q	ACH-000908	Gastric Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	0.2778
p.P716A	ACH-002039	Pancreatic Cancer	CCLE	PTPIRE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	DEG_SCF_FBW7_2	725:730	PTPIRE	FBXW7	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons