DegronMD

Uniprot ID: P98174

Source protein: FYVE, RhoGEF and PH domain-containing protein 1

Source gene: FGD1

Class: LIG_APCC_ABBA_1

Location: 612:617

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6282

ASA_SCORE: 17.1

COIL: 0.2415

CONS_SCORE: 0.5973

DSS_SCORE: 0.0288

HELIX: 0.042

FCONS_SCORE: 1.4773

RIG_SCORE: 0.9915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D609Y	TCGA-EE-A184	SKCM	TCGA	LILFND	LIG_APCC_ABBA_1	0.25
p.D609Y	DO47442	SKCM	ICGC	LILFND	LIG_APCC_ABBA_1	0.25
p.R610Q	TCGA-EO-A22U	UCEC	TCGA	LILFND	LIG_APCC_ABBA_1	0.2778
p.R610Q	DO43755	UCEC	ICGC	LILFND	LIG_APCC_ABBA_1	0.2778
p.P624S	TCGA-EY-A549	UCEC	TCGA	LILFND	LIG_APCC_ABBA_1	0.1389
p.P624S	DO48174	UCEC	ICGC	LILFND	LIG_APCC_ABBA_1	0.1389
p.R618S	TCGA-YY-A8LH	PAAD	TCGA	LILFND	LIG_APCC_ABBA_1	0.3056
p.R618S	DO50273	PAAD	ICGC	LILFND	LIG_APCC_ABBA_1	0.3056
p.V623M	DO222991	BTCA	ICGC	LILFND	LIG_APCC_ABBA_1	0.1667
p.V623M	DO233200	GACA	ICGC	LILFND	LIG_APCC_ABBA_1	0.1667
p.V623M	SIDM01413	Oral Cavity Carcinoma	GDSC	LILFND	LIG_APCC_ABBA_1	0.1667
p.Q608K	DO229029	LICA	ICGC	LILFND	LIG_APCC_ABBA_1	0.2222
p.D609E	DO229022	LICA	ICGC	LILFND	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98174	FYVE, RhoGEF and PH domain-containing protein 1	LIG_APCC_ABBA_1	612:617	LILFND	APC,CDC20,FZR1	0.6282	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons