DegronMD

Uniprot ID: Q5JSP0

Source protein: FYVE, RhoGEF and PH domain-containing protein 3

Source gene: FGD3

Class: DEG_SCF_SKP2-CKS1_1

Location: 135:142

E3 ligase: SKP2,CSK1

DEGRON score: 0.9959

ASA_SCORE: 99.5

COIL: 0.7706

CONS_SCORE: 0.3477

DSS_SCORE: 0.8451

HELIX: 0.2166

FCONS_SCORE: 1.0834

RIG_SCORE: 0.6016

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T139A	TCGA-BR-8360	STAD	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.825
p.T139A	DO47745	STAD	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.825
p.S136Y	TCGA-B5-A1MX	UCEC	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.712
p.S136Y	DO41999	UCEC	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.712
p.A143S	DO229024	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E133K	TCGA-EE-A3J5	SKCM	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E133K	DO222714	MELA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E133K	DO47331	SKCM	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E132D	SIDM01449	Pancreatic Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.E132D	ACH-000517	Pancreatic Cancer	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.G131V	TCGA-CR-7364	HNSC	TCGA	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.G131V	DO15679	HNSC	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D146N	DO222837	MELA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D129Y	DO228978	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A150S	DO222574	BTCA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.1111
p.D127E	DO50766	LICA	ICGC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A126V	SIDM01943	Colorectal Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A126V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A126V	SIDM01617	Endometrial Carcinoma	GDSC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A126V	ACH-000953	Leukemia	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A126V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A126V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSENTPQK	DEG_SCF_SKP2-CKS1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SCF_SKP2-CKS1_1	135:142	DSENTPQK	SKP2,CSK1	0.9959	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons