DegronMD

Uniprot ID: Q5JSP0

Source protein: FYVE, RhoGEF and PH domain-containing protein 3

Source gene: FGD3

Class: DEG_SPOP_SBC_1

Location: 498:502

E3 ligase: SPOP

DEGRON score: 0.9839

ASA_SCORE: 81.94

COIL: 0.9278

CONS_SCORE: 0.2634

DSS_SCORE: 0.6721

HELIX: 0.0264

FCONS_SCORE: 1.02

RIG_SCORE: 0.64

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P498H	TCGA-AP-A059	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	0.7694
p.P498H	DO41361	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	0.7694
p.E512K	TCGA-AP-A1DV	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	0.0556
p.E512K	TCGA-D1-A17Q	UCEC	TCGA	PITST	DEG_SPOP_SBC_1	0.0556
p.E512K	DO43186	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	0.0556
p.E512K	DO41903	UCEC	ICGC	PITST	DEG_SPOP_SBC_1	0.0556
p.E489K	TCGA-GV-A6ZA	BLCA	TCGA	PITST	DEG_SPOP_SBC_1	0.0833
p.E489K	DO49776	BLCA	ICGC	PITST	DEG_SPOP_SBC_1	0.0833
p.T500M	TCGA-HU-8602	STAD	TCGA	PITST	DEG_SPOP_SBC_1	0.7423
p.T500M	DO47829	STAD	ICGC	PITST	DEG_SPOP_SBC_1	0.7423
p.T510A	TCGA-P4-AAVM	KIRP	TCGA	PITST	DEG_SPOP_SBC_1	0.1111
p.T510A	DO219695	KIRP	ICGC	PITST	DEG_SPOP_SBC_1	0.1111
p.T510A	ACH-002059	Leukemia	CCLE	PITST	DEG_SPOP_SBC_1	0.1111
p.T510A	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PITST	DEG_SPOP_SBC_1	0.1111
p.T511I	DO233784	GACA	ICGC	PITST	DEG_SPOP_SBC_1	0.0833
p.V508E	DO228422	LICA	ICGC	PITST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	908:912	PITST	SPOP	0.9967	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3787:3791	PITST	SPOP	0.5313	More...
Q5JSP0	FYVE, RhoGEF and PH domain-containing protein 3	DEG_SPOP_SBC_1	498:502	PITST	SPOP	0.9839	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	125:129	PITST	SPOP	0.9804	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	259:263	PITST	SPOP	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons