DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PITST
Uniprot ID:
Q9BVL2
Source protein:
Nucleoporin p58/p45
Source gene:
NUP58
Class:
DEG_SPOP_SBC_1
Location:
125:129
E3 ligase:
SPOP
DEGRON score:
0.9804
ASA_SCORE:
75.74
COIL:
0.8756
CONS_SCORE:
0.3493
DSS_SCORE:
0.2719
HELIX:
0.0424
FCONS_SCORE:
0.838
RIG_SCORE:
0.7759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NUP58 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PITST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
908:912
PITST
SPOP
0.9967
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3787:3791
PITST
SPOP
0.5313
More...
Q5JSP0
FYVE, RhoGEF and PH domain-containing protein 3
DEG_SPOP_SBC_1
498:502
PITST
SPOP
0.9839
More...
Q9BVL2
Nucleoporin p58/p45
DEG_SPOP_SBC_1
125:129
PITST
SPOP
0.9804
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
259:263
PITST
SPOP
0.9811
More...