DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PITST
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
3787:3791
E3 ligase:
SPOP
DEGRON score:
0.5313
ASA_SCORE:
88.78
COIL:
0.763
CONS_SCORE:
0.3368
DSS_SCORE:
0.5943
HELIX:
0.0164
FCONS_SCORE:
1.2291
RIG_SCORE:
0.6952
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PITST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
908:912
PITST
SPOP
0.9967
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3787:3791
PITST
SPOP
0.5313
More...
Q5JSP0
FYVE, RhoGEF and PH domain-containing protein 3
DEG_SPOP_SBC_1
498:502
PITST
SPOP
0.9839
More...
Q9BVL2
Nucleoporin p58/p45
DEG_SPOP_SBC_1
125:129
PITST
SPOP
0.9804
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
259:263
PITST
SPOP
0.9811
More...