DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SCF_FBW7_1

Location: 640:647

E3 ligase: FBXW7

DEGRON score: 0.9844

ASA_SCORE: 84.3125

COIL: 0.804

CONS_SCORE: 0.3519

DSS_SCORE: 0.4194

HELIX: 0.0181

FCONS_SCORE: 0.9354

RIG_SCORE: 0.7336

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T643I	TCGA-05-4382	LUAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.7078
p.T643I	DO24900	LUAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.7078
p.P644S	TCGA-21-1079	LUSC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.6752
p.P644S	DO26846	LUSC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.6752
p.T632K	TCGA-95-A4VP	LUAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.1111
p.T632K	DO51201	LUAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.1111
p.G637A	TCGA-AA-3666	COAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.25
p.G637A	DO9042	COAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.25
p.F635L	TCGA-AP-A054	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.1944
p.F635L	DO42256	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.1944
p.L636F	TCGA-AZ-4315	COAD	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.2222
p.L636F	DO8842	COAD	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.2222
p.R650C	TCGA-D3-A8GS	SKCM	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.25
p.R650C	DO51248	SKCM	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.25
p.E652K	TCGA-DF-A2KV	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.1944
p.E652K	DO219771	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.1944
p.E654K	TCGA-E6-A1LX	UCEC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.E654K	DO41020	UCEC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.E654K	KYM-1	soft_tissue	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.E654K	GAK	skin	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.E654K	SNU-423	liver	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.E654K	MKN28	stomach	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1389
p.F656L	TCGA-MI-A75C	LIHC	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.0833
p.F656L	DO49705	LIHC	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.0833
p.P646L	TCGA-ZF-A9RL	BLCA	TCGA	LSTTPFPS	DEG_SCF_FBW7_1	0.6471
p.P646L	DO219078	BLCA	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.6471
p.P657S	DO220907	MELA	ICGC	LSTTPFPS	DEG_SCF_FBW7_1	0.0556
p.R630G	SIDM01090	Colorectal Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	0.0556
p.R630G	ACH-000943	Colon/Colorectal Cancer	CCLE	LSTTPFPS	DEG_SCF_FBW7_1	0.0556
p.R630G	RKO	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.0556
p.P644L	SIDM00855	Other Sarcomas	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	0.7582
p.P644L	SIDM00125	Kidney Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	0.7582
p.P644L	SIDM01083	Oral Cavity Carcinoma	GDSC	LSTTPFPS	DEG_SCF_FBW7_1	0.7582
p.D634N	ACH-000881	Skin Cancer	CCLE	LSTTPFPS	DEG_SCF_FBW7_1	0.1667
p.D634N	MEL-JUSO	skin	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1667
p.R638I	SNU-81	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.2778
p.S647Y	SNU-81	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.8231
p.S655Y	CW-2	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1111
p.E634D	HT-115	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.1667
p.G645E	HCT-15	large_intestine	COSMIC	LSTTPFPS	DEG_SCF_FBW7_1	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTTPFPS

Degron related mutations and impact score

Drug responses associated with VCAN mutations

All proteins holding degron of LSTTPFPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SCF_FBW7_1	640:647	LSTTPFPS	FBXW7	0.9844	More...