DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SIAH_1

Location: 1695:1703

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.8599

ASA_SCORE: 88.0667

COIL: 0.7811

CONS_SCORE: 0.4343

DSS_SCORE: 0.3595

HELIX: 0.0179

FCONS_SCORE: 0.922

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1712Y	TCGA-A5-A2K5	UCEC	TCGA	QPSAKVVPT	DEG_SIAH_1	0.0833
p.S1712Y	DO41379	UCEC	ICGC	QPSAKVVPT	DEG_SIAH_1	0.0833
p.D1710Y	TCGA-AP-A051	UCEC	TCGA	QPSAKVVPT	DEG_SIAH_1	0.1389
p.D1710Y	DO8730	COAD	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1389
p.D1710Y	DO42673	UCEC	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1389
p.E1708K	TCGA-BF-AAP2	SKCM	TCGA	QPSAKVVPT	DEG_SIAH_1	0.1944
p.E1708K	DO219466	SKCM	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1944
p.D1710N	TCGA-BR-4201	STAD	TCGA	QPSAKVVPT	DEG_SIAH_1	0.1389
p.D1710N	DO38707	STAD	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1389
p.I1689V	TCGA-DK-A3IU	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	0.1667
p.I1689V	DO612	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1667
p.P1702L	TCGA-F5-6814	READ	TCGA	QPSAKVVPT	DEG_SIAH_1	0.7582
p.P1702L	DO36556	READ	ICGC	QPSAKVVPT	DEG_SIAH_1	0.7582
p.T1703A	TCGA-XF-A9SY	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	0.6028
p.T1703A	DO51918	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	0.6028
p.T1709K	TCGA-XF-AAMF	BLCA	TCGA	QPSAKVVPT	DEG_SIAH_1	0.1667
p.T1709K	DO51930	BLCA	ICGC	QPSAKVVPT	DEG_SIAH_1	0.1667
p.A1698T	DO52722	CLLE	ICGC	QPSAKVVPT	DEG_SIAH_1	0.7139
p.Q1695H	DO50408	ESAD	ICGC	QPSAKVVPT	DEG_SIAH_1	0.647
p.V1706I	DO218774	GACA	ICGC	QPSAKVVPT	DEG_SIAH_1	0.25
p.P1691S	DO228011	SKCA	ICGC	QPSAKVVPT	DEG_SIAH_1	0.2222
p.P1709S	Mewo	skin	COSMIC	QPSAKVVPT	DEG_SIAH_1	0.1667
p.R1710P	OAW-42	ovary	COSMIC	QPSAKVVPT	DEG_SIAH_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SIAH_1	1695:1703	QPSAKVVPT	SIAH1,SIAH2,SIAH3	0.8599	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons