DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SCF_FBW7_1

Location: 3055:3061

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 78.7714

COIL: 0.8783

CONS_SCORE: 0.4812

DSS_SCORE: 0.4383

HELIX: 0.0214

FCONS_SCORE: 0.9404

RIG_SCORE: 0.7918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3059S	TCGA-18-3409	LUSC	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.5641
p.P3059S	DO26444	LUSC	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.5641
p.E3054D	TCGA-21-5787	LUSC	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.3056
p.E3054D	DO26605	LUSC	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.3056
p.D3070N	TCGA-2W-A8YY	CESC	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.0833
p.D3070N	DO223732	CESC	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.0833
p.V3055I	TCGA-B5-A1MX	UCEC	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.5965
p.V3055I	DO41999	UCEC	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.5965
p.V3055L	TCGA-DD-AACA	LIHC	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.5654
p.V3055L	DO52196	LIHC	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.5654
p.S3061F	TCGA-EB-A4IS	SKCM	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.7982
p.S3061F	TCGA-YD-A9TB	SKCM	TCGA	VATPPFS	DEG_SCF_FBW7_1	0.7982
p.S3061F	DO47281	SKCM	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.7982
p.S3061F	DO51297	SKCM	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.7982
p.D3070Y	DO230336	COCA	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.0833
p.T3053A	DO233885	GACA	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.2778
p.A3056S	DO229031	LICA	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.6477
p.P3059T	DO23551	LIRI	ICGC	VATPPFS	DEG_SCF_FBW7_1	0.5919
p.E3050K	SIDM00217	Colorectal Carcinoma	GDSC	VATPPFS	DEG_SCF_FBW7_1	0.1944
p.E3050K	ACH-000999	Colon/Colorectal Cancer	CCLE	VATPPFS	DEG_SCF_FBW7_1	0.1944
p.E3050K	SNU-1040	large_intestine	COSMIC	VATPPFS	DEG_SCF_FBW7_1	0.1944
p.V3055A	SIDM01059	Melanoma	GDSC	VATPPFS	DEG_SCF_FBW7_1	0.6936
p.V3055A	ACH-000915	Skin Cancer	CCLE	VATPPFS	DEG_SCF_FBW7_1	0.6936
p.V3055A	IPC-298	skin	COSMIC	VATPPFS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SCF_FBW7_1	3055:3061	VATPPFS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons