DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 1740:1744

E3 ligase: SPOP

DEGRON score: 0.8735

ASA_SCORE: 80.34

COIL: 0.6248

CONS_SCORE: 0.372

DSS_SCORE: 0.477

HELIX: 0.0208

FCONS_SCORE: 0.8703

RIG_SCORE: 0.7827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1754I	TCGA-17-Z022	LUAD	TCGA	VYSST	DEG_SPOP_SBC_1	0.0556
p.G1730R	TCGA-EB-A85I	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	0.0556
p.G1730R	DO50296	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	0.0556
p.T1734S	TCGA-FR-A7U9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	0.1667
p.T1734S	DO48546	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	0.1667
p.T1734M	TCGA-FR-A7U9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	0.1667
p.T1734M	DO48546	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	0.1667
p.P1753S	TCGA-GF-A6C9	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	0.0833
p.P1753S	DO51254	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	0.0833
p.S1747L	TCGA-VQ-A8PB	STAD	TCGA	VYSST	DEG_SPOP_SBC_1	0.25
p.S1747L	DO233118	GACA	ICGC	VYSST	DEG_SPOP_SBC_1	0.25
p.S1747L	DO229177	LMS	ICGC	VYSST	DEG_SPOP_SBC_1	0.25
p.S1747L	DO51766	STAD	ICGC	VYSST	DEG_SPOP_SBC_1	0.25
p.T1731P	TCGA-YD-A9TA	SKCM	TCGA	VYSST	DEG_SPOP_SBC_1	0.0833
p.T1731P	DO219503	SKCM	ICGC	VYSST	DEG_SPOP_SBC_1	0.0833
p.G1730E	DO222632	MELA	ICGC	VYSST	DEG_SPOP_SBC_1	0.0556
p.S1743A	SIDM00193	Colorectal Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	0.7588
p.S1743A	ACH-000991	Colon/Colorectal Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	0.7588
p.S1743A	SNU-81	large_intestine	COSMIC	VYSST	DEG_SPOP_SBC_1	0.7588
p.T1737I	SIDM00092	Ovarian Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	0.25
p.T1737I	ACH-000617	Ovarian Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	0.25
p.T1737I	OVCAR-4	ovary	COSMIC	VYSST	DEG_SPOP_SBC_1	0.25
p.E1739D	ACH-000937	Leukemia	CCLE	VYSST	DEG_SPOP_SBC_1	0.3056
p.I1751M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VYSST	DEG_SPOP_SBC_1	0.1389
p.G1741D	CP66-MEL	skin	COSMIC	VYSST	DEG_SPOP_SBC_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	414:418	VYSST	SPOP	0.9819	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1740:1744	VYSST	SPOP	0.8735	More...
Q9NR34	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	DEG_SPOP_SBC_1	568:572	VYSST	SPOP	0.5468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons