DegronMD

Uniprot ID: Q9NR34

Source protein: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Source gene: MAN1C1

Class: DEG_SPOP_SBC_1

Location: 568:572

E3 ligase: SPOP

DEGRON score: 0.5468

ASA_SCORE: 70.18

COIL: 0.9478

CONS_SCORE: 0.3782

DSS_SCORE: 0.3701

HELIX: 0.0144

FCONS_SCORE: 0.7518

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A560T	TCGA-AP-A056	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	0.1111
p.Q580H	TCGA-AX-A2HD	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	0.1111
p.V568M	TCGA-B5-A0K9	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	0.7208
p.T558A	TCGA-DU-6392	LGG	TCGA	VYSST	DEG_SPOP_SBC_1	0.0556
p.P573A	TCGA-SX-A7SM	KIRP	TCGA	VYSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	414:418	VYSST	SPOP	0.9819	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1740:1744	VYSST	SPOP	0.8735	More...
Q9NR34	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	DEG_SPOP_SBC_1	568:572	VYSST	SPOP	0.5468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons