DegronMD - Q9NR34(MAN1C1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L52H	TCGA-34-5231	LUSC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2778
p.L52H	DO26772	LUSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2778
p.A560T	TCGA-AP-A056	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1111
p.R51C	TCGA-AX-A2HD	UCEC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.25
p.R51C	DO42608	UCEC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.25
p.Q580H	TCGA-AX-A2HD	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1111
p.V568M	TCGA-B5-A0K9	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	568:572	Mutation altering degron motif	0.7208
p.L63V	TCGA-CQ-5326	HNSC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.5654
p.L63V	DO15286	HNSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.5654
p.T558A	TCGA-DU-6392	LGG	TCGA	VYSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0556
p.A55P	TCGA-HU-A4G8	STAD	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.A55P	DO47819	STAD	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P573A	TCGA-SX-A7SM	KIRP	TCGA	VYSST	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.3056
p.H72N	DO222718	COCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.1389
p.R57Q	DO222884	COCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.6218
p.E68K	DO218136	GACA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.25
p.P69T	DO14210	HNSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2222
p.P69T	DO231286	THCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2222
p.G59E	DO50301	SKCM	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7199
p.R52Q	DO51275	SKCM	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2778
p.T46I	DO43186	UCEC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.1111
p.G62D	SIDM02021	Esophageal Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.6087
p.Q60K	SIDM00973	Melanoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.5833
p.Q60K	ACH-000827	Skin Cancer	CCLE	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.5833
p.P56A	SIDM00672	Hepatocellular Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P56A	SIDM00875	Breast Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P56A	SIDM00793	Burkitt's Lymphoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P56A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P56A	SIDM01664	Prostate Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.7503
p.P56S	SIDM00243	Other Solid Cancers	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.6752
p.P56S	NEC8	testis	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation altering degron motif	0.6752
p.R48S	ACH-001853	Bile Duct Cancer	CCLE	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.1667
p.R53H	NCI-H1155	lung	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.3056
p.I52T	MFE-319	endometrium	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	54:65	Mutation rewiring degron network	0.2778

Kaplan plot for MAN1C1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAN1C1

UniProt ID: Q9NR34

Entrez ID: 57134

Protein name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (HMIC) (Mannosidase alpha class 1C member 1) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAN1C1 in