DegronMD

Uniprot ID: Q9NR34

Source protein: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Source gene: MAN1C1

Class: DEG_ODPH_VHL_1

Location: 54:65

E3 ligase: VHL

DEGRON score: 0.8145

ASA_SCORE: 79.3417

COIL: 0.7138

CONS_SCORE: 0.2176

DSS_SCORE: 0.3033

HELIX: 0.2432

FCONS_SCORE: 0.814

RIG_SCORE: 0.7324

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L52H	TCGA-34-5231	LUSC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2778
p.L52H	DO26772	LUSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2778
p.R51C	TCGA-AX-A2HD	UCEC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.25
p.R51C	DO42608	UCEC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.25
p.L63V	TCGA-CQ-5326	HNSC	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.5654
p.L63V	DO15286	HNSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.5654
p.A55P	TCGA-HU-A4G8	STAD	TCGA	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.A55P	DO47819	STAD	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.H72N	DO222718	COCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.1389
p.R57Q	DO222884	COCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.6218
p.E68K	DO218136	GACA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.25
p.P69T	DO14210	HNSC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2222
p.P69T	DO231286	THCA	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2222
p.G59E	DO50301	SKCM	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7199
p.R52Q	DO51275	SKCM	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2778
p.T46I	DO43186	UCEC	ICGC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.1111
p.G62D	SIDM02021	Esophageal Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.6087
p.Q60K	SIDM00973	Melanoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.5833
p.Q60K	ACH-000827	Skin Cancer	CCLE	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.5833
p.P56A	SIDM00672	Hepatocellular Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.P56A	SIDM00875	Breast Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.P56A	SIDM00793	Burkitt's Lymphoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.P56A	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.P56A	SIDM01664	Prostate Carcinoma	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.7503
p.P56S	SIDM00243	Other Solid Cancers	GDSC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.6752
p.P56S	NEC8	testis	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.6752
p.R48S	ACH-001853	Bile Duct Cancer	CCLE	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.1667
p.R53H	NCI-H1155	lung	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.3056
p.I52T	MFE-319	endometrium	COSMIC	LAPRTQQPGLEV	DEG_ODPH_VHL_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPRTQQPGLEV

Degron related mutations and impact score

Drug responses associated with MAN1C1 mutations

All proteins holding degron of LAPRTQQPGLEV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR34	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	DEG_ODPH_VHL_1	54:65	LAPRTQQPGLEV	VHL	0.8145	More...