DegronMD - O75113(N4BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V799F	TCGA-34-7107	LUSC	TCGA	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1944
p.V799F	DO26449	LUSC	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1944
p.S245F	TCGA-52-7810	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation blocking phosphorylation signal	0.5278
p.S245F	DO27381	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation blocking phosphorylation signal	0.5278
p.S416N	TCGA-A5-A0G2	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.818
p.S416N	DO41235	UCEC	ICGC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.818
p.S416I	TCGA-AX-A05Z	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.8453
p.S416I	DO40884	UCEC	ICGC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.8453
p.T430A	TCGA-AX-A06F	UCEC	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.3056
p.T430A	DO41752	UCEC	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.3056
p.R280T	TCGA-BA-A6DA	HNSC	TCGA	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.1667
p.R280T	DO44448	HNSC	ICGC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.1667
p.Y415H	TCGA-CA-6717	COAD	TCGA	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7229
p.Y415H	DO8264	COAD	ICGC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7229
p.H433Y	TCGA-CK-4951	COAD	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.2222
p.H433Y	DO10582	COAD	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.2222
p.R280I	TCGA-D1-A17Q	UCEC	TCGA	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.1667
p.R280I	DO41903	UCEC	ICGC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.1667
p.E155D	TCGA-D3-A2JC	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.E155D	DO47578	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1111
p.K144N	TCGA-DD-AAE7	LIHC	TCGA	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.6918
p.K144N	DO52262	LIHC	ICGC	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.6918
p.S277P	TCGA-DI-A1BU	UCEC	TCGA	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.25
p.S277P	DO42023	UCEC	ICGC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.25
p.P812L	TCGA-EO-A22U	UCEC	TCGA	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.P812L	DO43755	UCEC	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.E145D	TCGA-EO-A3AV	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.6758
p.E145D	DO52412	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation altering degron motif	0.6758
p.P800H	TCGA-HC-7081	PRAD	TCGA	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.P800H	DO49789	PRAD	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.S245P	TCGA-HU-A4GX	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation blocking phosphorylation signal	0.5278
p.S245P	DO47757	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation blocking phosphorylation signal	0.5278
p.D424N	TCGA-JW-A5VL	CESC	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation altering degron motif	0.6932
p.D424N	DO49976	CESC	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation altering degron motif	0.6932
p.G817V	TCGA-K4-A5RH	BLCA	TCGA	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0833
p.G817V	DO219028	BLCA	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0833
p.V439L	DO225280	BRCA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.0556
p.R280S	DO222762	COCA	ICGC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.1667
p.T813A	DO233276	GACA	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.1944
p.Q136K	DO229029	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	143:147	Mutation rewiring degron network	0.1389
p.T426N	DO229032	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation altering degron motif	0.8166
p.T430K	DO229037	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.3056
p.Q435K	DO229045	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.1667
p.G801D	DO50970	LICA	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.25
p.I266V	DO32936	PACA	ICGC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation rewiring degron network	0.25
p.I266V	DO32936	PACA	ICGC	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1111
p.L255I	DO36556	READ	ICGC	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation altering degron motif	0.6063
p.P795S	DO229229	THCA	ICGC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.0833
p.Q431R	SIDM00683	Prostate Carcinoma	GDSC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.2778
p.Q431R	ACH-000977	lymph node	CCLE	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.2778
p.Q431R	LNCaP-Clone-FGC	prostate	COSMIC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.2778
p.Y415C	SIDM00499	Prostate Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7087
p.Y415C	ACH-000459	Kidney Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7087
p.Y415C	ACH-000956	Prostate Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7087
p.Y415C	22RV1	prostate	COSMIC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7087
p.R517G	SIDM00845	Burkitt's Lymphoma	GDSC	RVPLFPE	LIG_APCC_ABBAyCdc20_2	517:523	Mutation altering degron motif	0.7568
p.R517G	ACH-000786	Lymphoma	CCLE	RVPLFPE	LIG_APCC_ABBAyCdc20_2	517:523	Mutation altering degron motif	0.7568
p.R517G	Daudi	haematopoietic and lymphoid tissue	COSMIC	RVPLFPE	LIG_APCC_ABBAyCdc20_2	517:523	Mutation altering degron motif	0.7568
p.P812S	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.P812S	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	AASTS	DEG_SPOP_SBC_1	804:808	Mutation rewiring degron network	0.2222
p.T270A	SIDM01218	Other Solid Cancers	GDSC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation altering degron motif	0.825
p.T270A	ACH-001530	Endometrial/Uterine Cancer	CCLE	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation altering degron motif	0.825
p.T270A	JEG-3	placenta	COSMIC	LTPDEE	DEG_SCF_FBW7_2	269:274	Mutation altering degron motif	0.825
p.N419D	SIDM00214	Colorectal Carcinoma	GDSC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.25
p.N419D	SIDM00214	Colorectal Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.N419D	ACH-000955	Colon/Colorectal Cancer	CCLE	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.25
p.N419D	ACH-000955	Colon/Colorectal Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.N419D	SNU-407	large intestine	COSMIC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	422:429	Mutation rewiring degron network	0.25
p.N419D	SNU-407	large intestine	COSMIC	VYSST	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.3056
p.L247R	SIDM01578	Bladder Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.L247R	ACH-000862	Bladder Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.1389
p.V507G	ACH-001164	Sarcoma	CCLE	RVPLFPE	LIG_APCC_ABBAyCdc20_2	517:523	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

N4BP1

UniProt ID: O75113

Entrez ID: 9683

Protein name: NEDD4-binding protein 1 (N4BP1) (EC 3.1.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for N4BP1 in