DegronMD

Uniprot ID: O75113

Source protein: NEDD4-binding protein 1

Source gene: N4BP1

Class: DEG_SCF_FBW7_2

Location: 269:274

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 84.0167

COIL: 0.6728

CONS_SCORE: 0.3739

DSS_SCORE: 0.4695

HELIX: 0.3035

FCONS_SCORE: 1.0613

RIG_SCORE: 0.7309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R280T	TCGA-BA-A6DA	HNSC	TCGA	LTPDEE	DEG_SCF_FBW7_2	0.1667
p.R280T	DO44448	HNSC	ICGC	LTPDEE	DEG_SCF_FBW7_2	0.1667
p.R280I	TCGA-D1-A17Q	UCEC	TCGA	LTPDEE	DEG_SCF_FBW7_2	0.1667
p.R280I	DO41903	UCEC	ICGC	LTPDEE	DEG_SCF_FBW7_2	0.1667
p.S277P	TCGA-DI-A1BU	UCEC	TCGA	LTPDEE	DEG_SCF_FBW7_2	0.25
p.S277P	DO42023	UCEC	ICGC	LTPDEE	DEG_SCF_FBW7_2	0.25
p.R280S	DO222762	COCA	ICGC	LTPDEE	DEG_SCF_FBW7_2	0.1667
p.I266V	DO32936	PACA	ICGC	LTPDEE	DEG_SCF_FBW7_2	0.25
p.T270A	SIDM01218	Other Solid Cancers	GDSC	LTPDEE	DEG_SCF_FBW7_2	0.825
p.T270A	ACH-001530	Endometrial/Uterine Cancer	CCLE	LTPDEE	DEG_SCF_FBW7_2	0.825
p.T270A	JEG-3	placenta	COSMIC	LTPDEE	DEG_SCF_FBW7_2	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	DEG_SCF_FBW7_2	269:274	LTPDEE	FBXW7	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons