DegronMD

Uniprot ID: O75113

Source protein: NEDD4-binding protein 1

Source gene: N4BP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 517:523

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9616

ASA_SCORE: 86.5143

COIL: 0.854

CONS_SCORE: 0.2466

DSS_SCORE: 0.6521

HELIX: 0.0467

FCONS_SCORE: 0.762

RIG_SCORE: 0.6648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R517G	SIDM00845	Burkitt's Lymphoma	GDSC	RVPLFPE	LIG_APCC_ABBAyCdc20_2	0.7568
p.R517G	ACH-000786	Lymphoma	CCLE	RVPLFPE	LIG_APCC_ABBAyCdc20_2	0.7568
p.R517G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RVPLFPE	LIG_APCC_ABBAyCdc20_2	0.7568
p.V507G	ACH-001164	Sarcoma	CCLE	RVPLFPE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	LIG_APCC_ABBAyCdc20_2	517:523	RVPLFPE	APC,CDC20,FZR1	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons