DegronMD

Uniprot ID: O75113

Source protein: NEDD4-binding protein 1

Source gene: N4BP1

Class: DEG_SPOP_SBC_1

Location: 414:418

E3 ligase: SPOP

DEGRON score: 0.9819

ASA_SCORE: 87.24

COIL: 0.8784

CONS_SCORE: 0.289

DSS_SCORE: 0.5737

HELIX: 0.0558

FCONS_SCORE: 0.8739

RIG_SCORE: 0.6913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S416N	TCGA-A5-A0G2	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	0.818
p.S416N	DO41235	UCEC	ICGC	VYSST	DEG_SPOP_SBC_1	0.818
p.S416I	TCGA-AX-A05Z	UCEC	TCGA	VYSST	DEG_SPOP_SBC_1	0.8453
p.S416I	DO40884	UCEC	ICGC	VYSST	DEG_SPOP_SBC_1	0.8453
p.Y415H	TCGA-CA-6717	COAD	TCGA	VYSST	DEG_SPOP_SBC_1	0.7229
p.Y415H	DO8264	COAD	ICGC	VYSST	DEG_SPOP_SBC_1	0.7229
p.Y415C	SIDM00499	Prostate Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	0.7087
p.Y415C	ACH-000459	Kidney Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	0.7087
p.Y415C	ACH-000956	Prostate Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	0.7087
p.Y415C	22RV1	prostate	COSMIC	VYSST	DEG_SPOP_SBC_1	0.7087
p.N419D	SIDM00214	Colorectal Carcinoma	GDSC	VYSST	DEG_SPOP_SBC_1	0.3056
p.N419D	ACH-000955	Colon/Colorectal Cancer	CCLE	VYSST	DEG_SPOP_SBC_1	0.3056
p.N419D	SNU-407	large_intestine	COSMIC	VYSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	414:418	VYSST	SPOP	0.9819	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	1740:1744	VYSST	SPOP	0.8735	More...
Q9NR34	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	DEG_SPOP_SBC_1	568:572	VYSST	SPOP	0.5468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons