DegronMD

Uniprot ID: O75113

Source protein: NEDD4-binding protein 1

Source gene: N4BP1

Class: DEG_SCF_SKP2-CKS1_1

Location: 422:429

E3 ligase: SKP2,CSK1

DEGRON score: 0.9197

ASA_SCORE: 97.7875

COIL: 0.8201

CONS_SCORE: 0.3366

DSS_SCORE: 0.6112

HELIX: 0.1546

FCONS_SCORE: 1.1566

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T430A	TCGA-AX-A06F	UCEC	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T430A	DO41752	UCEC	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.H433Y	TCGA-CK-4951	COAD	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.H433Y	DO10582	COAD	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D424N	TCGA-JW-A5VL	CESC	TCGA	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.6932
p.D424N	DO49976	CESC	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.6932
p.V439L	DO225280	BRCA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T426N	DO229032	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.8166
p.T430K	DO229037	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.Q435K	DO229045	LICA	ICGC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q431R	SIDM00683	Prostate Carcinoma	GDSC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.Q431R	ACH-000977	lymph_node	CCLE	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.Q431R	LNCaP-Clone-FGC	prostate	COSMIC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.N419D	SIDM00214	Colorectal Carcinoma	GDSC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.N419D	ACH-000955	Colon/Colorectal Cancer	CCLE	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.25
p.N419D	SNU-407	large_intestine	COSMIC	TTDSTPKK	DEG_SCF_SKP2-CKS1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75113	NEDD4-binding protein 1	DEG_SCF_SKP2-CKS1_1	422:429	TTDSTPKK	SKP2,CSK1	0.9197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons