DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
P13611
Source protein:
Versican core protein
Source gene:
VCAN
Class:
ITCH
Location:
2804:2807
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.882
ASA_SCORE:
98.25
COIL:
0.78
CONS_SCORE:
0.4492
DSS_SCORE:
0.4216
HELIX:
0.0298
FCONS_SCORE:
1.0522
RIG_SCORE:
0.7292
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E2800D
TCGA-66-2767
LUSC
TCGA
PPYY
ITCH
0.2222
p.E2800D
DO26713
LUSC
ICGC
PPYY
ITCH
0.2222
p.M2799T
TCGA-BH-A0EE
BRCA
TCGA
PPYY
ITCH
0.1944
p.M2799T
DO6088
BRCA
ICGC
PPYY
ITCH
0.1944
p.S2802T
TCGA-D5-6931
COAD
TCGA
PPYY
ITCH
0.2778
p.S2802T
DO8384
COAD
ICGC
PPYY
ITCH
0.2778
p.L2812S
TCGA-N7-A4Y0
UCS
TCGA
PPYY
ITCH
0.1944
p.T2810S
TCGA-O2-A52Q
LUSC
TCGA
PPYY
ITCH
0.25
p.T2810S
DO219219
LUSC
ICGC
PPYY
ITCH
0.25
p.N2803S
TCGA-S8-A6BW
ESCA
TCGA
PPYY
ITCH
0.3056
p.P2804L
TCGA-Z2-A8RT
SKCM
TCGA
PPYY
ITCH
0.7582
p.P2804L
DO51301
SKCM
ICGC
PPYY
ITCH
0.7582
p.P2804S
DO229249
LMS
ICGC
PPYY
ITCH
0.6752
p.M2799I
DO222843
MELA
ICGC
PPYY
ITCH
0.1944
p.S2802F
DO219878
SKCA
ICGC
PPYY
ITCH
0.2778
p.T2816P
SIDM00850
Gastric Carcinoma
GDSC
PPYY
ITCH
0.0833
p.T2816P
ACH-000880
Gastric Cancer
CCLE
PPYY
ITCH
0.0833
p.T2816P
AGS
stomach
COSMIC
PPYY
ITCH
0.0833
Drug responses associated with VCAN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...