DegronMD

Uniprot ID: Q5JSJ4

Source protein: Integrator complex subunit 6-like

Source gene: INTS6L

Class: ITCH

Location: 424:427

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9555

ASA_SCORE: 49.725

COIL: 0.3695

CONS_SCORE: 0.6688

DSS_SCORE: 0.08

HELIX: 0.6185

FCONS_SCORE: 1.5009

RIG_SCORE: 0.8836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L429I	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	0.2778
p.L429I	SIDM00461	Acute Myeloid Leukemia	GDSC	PPYY	ITCH	0.2778
p.L429I	SIDM01519	Head and Neck Carcinoma	GDSC	PPYY	ITCH	0.2778
p.R436G	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons