DegronMD - O94915(FRYL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2451C	TCGA-06-5416	GBM	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	TCGA-AA-A010	COAD	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	TCGA-F5-6814	READ	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	TCGA-FI-A2D0	UCEC	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	DO10880	GBM	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	DO36556	READ	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	DO43891	UCEC	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	SIDM01043	Other Sarcomas	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	SIDM00193	Colorectal Carcinoma	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	ACH-000913	Endometrial/Uterine Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	ACH-000991	Colon/Colorectal Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	SNU-81	large intestine	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R2451C	ESS-1	endometrium	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.719
p.R96K	TCGA-17-Z016	LUAD	TCGA	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.3056
p.R98W	TCGA-19-5956	GBM	TCGA	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7523
p.R98W	DO13863	GBM	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7523
p.S1454P	TCGA-55-8506	LUAD	TCGA	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.1111
p.S1454P	DO45390	LUAD	ICGC	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.1111
p.S1507N	TCGA-75-5126	LUAD	TCGA	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.S1507N	DO23711	LUAD	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.K1472R	TCGA-78-7535	LUAD	TCGA	PPYY	ITCH	1462:1465	Mutation substituting flanking lysine	0.25
p.K1472R	DO24860	LUAD	ICGC	PPYY	ITCH	1462:1465	Mutation substituting flanking lysine	0.25
p.D2462N	TCGA-A5-A2K5	UCEC	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.25
p.D2462N	DO41379	UCEC	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.25
p.D1492Y	TCGA-AX-A05Z	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.1111
p.D1492Y	DO40884	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.1111
p.L1511P	TCGA-B5-A11J	UCEC	TCGA	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.1389
p.L1511P	DO43698	UCEC	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.1389
p.T88M	TCGA-BR-4370	STAD	TCGA	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.T88M	DO223048	ESCA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.T88M	DO38499	STAD	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.E1506D	TCGA-CR-7395	HNSC	TCGA	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.2778
p.E1506D	DO14274	HNSC	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.2778
p.G87R	TCGA-D5-6924	COAD	TCGA	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0556
p.G87R	DO7922	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0556
p.D2456N	TCGA-DK-A1AC	BLCA	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.5821
p.D2456N	DO514	BLCA	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.5821
p.R110C	TCGA-DU-6392	LGG	TCGA	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.R110C	DO22237	LGG	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.F2446L	TCGA-KH-A6WC	ESCA	TCGA	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1944
p.Y1471F	TCGA-LN-A49R	ESCA	TCGA	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.1667
p.R101Q	DO51883	BLCA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7329
p.R101Q	DO1263	BRCA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7329
p.R101Q	DO10172	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7329
p.R101Q	DO41133	UCEC	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7329
p.D1496N	DO228483	BRCA	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.2222
p.D1496N	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.2222
p.D1496N	ACH-000813	Lung Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.2222
p.N1494K	DO222468	BTCA	ICGC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.1667
p.V2450G	DO6458	CLLE	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.3056
p.V2450G	DO45129	LIRI	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.3056
p.R87C	DO8730	COAD	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0556
p.D2444G	DO230311	COCA	ICGC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.1389
p.S100I	DO223155	ESCA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.8453
p.R1466H	DO233737	GACA	ICGC	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.3056
p.P1463L	DO233882	GACA	ICGC	PPYY	ITCH	1462:1465	Mutation altering degron motif	0.7582
p.R87S	DO228974	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0556
p.T88K	DO229035	LICA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.E94V	DO228338	MALY	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.E94V	SIDM00948	Burkitt's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.E94V	ACH-002232	Lymphoma	CCLE	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.E94V	DG-75	haematopoietic and lymphoid tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.R106C	DO222743	MELA	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1944
p.R1466C	DO218900	SKCA	ICGC	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.3056
p.S90I	DO37631	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1389
p.P97L	DO47368	SKCM	ICGC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7582
p.T1468A	SIDM00625	Other Sarcomas	GDSC	PPYY	ITCH	1462:1465	Mutation rewiring degron network	0.25
p.I1500V	SIDM00212	Glioblastoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation altering degron motif	0.5965
p.I1500V	ACH-000464	Brain Cancer	CCLE	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation altering degron motif	0.5965
p.I1500V	CAS-1	central nervous system	COSMIC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation altering degron motif	0.5965
p.N1497I	SIDM01248	Thyroid Gland Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.N1497I	SIDM00042	Pancreatic Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.N1497I	SIDM00063	Melanoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.N1497I	SIDM01009	Neuroblastoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.N1497I	SIDM00699	Small Cell Lung Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.N1497I	SIDM01167	Thyroid Gland Carcinoma	GDSC	IKENI	DEG_APCC_KENBOX_2	1500:1504	Mutation rewiring degron network	0.25
p.G105R	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.2222
p.G105R	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PRSST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.2222
p.R2453H	SIDM00534	Colorectal Carcinoma	GDSC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.7133
p.R2453H	ACH-000986	Colon/Colorectal Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.7133
p.R2453H	HT-115	large intestine	COSMIC	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation altering degron motif	0.7133
p.Y1464H	SIDM01608	Endometrial Carcinoma	GDSC	PPYY	ITCH	1462:1465	Mutation altering degron motif	0.6118
p.Y1464H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPYY	ITCH	1462:1465	Mutation altering degron motif	0.6118
p.Y95C	ACH-001510	Head and Neck Cancer	CCLE	PRSST	DEG_SPOP_SBC_1	97:101	Mutation blocking phosphorylation signal	0.7222
p.E2468K	ACH-001569	Skin Cancer	CCLE	RRRSLDSID	DEG_APCC_DBOX_1	2451:2459	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRYL

UniProt ID: O94915

Entrez ID: 285527

Protein name: Protein furry homolog-like (ALL1-fused gene from chromosome 4p12 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRYL in