DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
O94915
Source protein:
Protein furry homolog-like
Source gene:
FRYL
Class:
ITCH
Location:
1462:1465
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9735
ASA_SCORE:
50.825
COIL:
0.6935
CONS_SCORE:
0.3771
DSS_SCORE:
0.4146
HELIX:
0.034
FCONS_SCORE:
1.2523
RIG_SCORE:
0.7635
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1454P
TCGA-55-8506
LUAD
TCGA
PPYY
ITCH
0.1111
p.S1454P
DO45390
LUAD
ICGC
PPYY
ITCH
0.1111
p.K1472R
TCGA-78-7535
LUAD
TCGA
PPYY
ITCH
0.25
p.K1472R
DO24860
LUAD
ICGC
PPYY
ITCH
0.25
p.Y1471F
TCGA-LN-A49R
ESCA
TCGA
PPYY
ITCH
0.1667
p.R1466H
DO233737
GACA
ICGC
PPYY
ITCH
0.3056
p.P1463L
DO233882
GACA
ICGC
PPYY
ITCH
0.7582
p.R1466C
DO218900
SKCA
ICGC
PPYY
ITCH
0.3056
p.T1468A
SIDM00625
Other Sarcomas
GDSC
PPYY
ITCH
0.25
p.Y1464H
SIDM01608
Endometrial Carcinoma
GDSC
PPYY
ITCH
0.6118
p.Y1464H
ACH-000990
Endometrial/Uterine Cancer
CCLE
PPYY
ITCH
0.6118
Drug responses associated with FRYL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...