DegronMD - Q13310(PABPC4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R491H	TCGA-06-5416	GBM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.8244
p.R491H	SIDM00837	Colorectal Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.8244
p.R491H	SW48	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.8244
p.D490Y	TCGA-33-4583	LUSC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.3056
p.P489L	TCGA-33-4583	LUSC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2778
p.A493G	TCGA-61-1907	OV	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.754
p.R463H	TCGA-76-4929	GBM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.R463H	TCGA-AB-2806	LAML	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.R463H	TCGA-F5-6814	READ	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.R463H	DO12772	GBM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.R463H	DO21283	LAML	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.R463H	DO36556	READ	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7133
p.A466T	TCGA-AA-3950	COAD	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.A466T	TCGA-AA-3950	COAD	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7139
p.A466T	DO9202	COAD	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.A466T	DO9202	COAD	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7139
p.A466T	DO233135	GACA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.A466T	DO233135	GACA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7139
p.P411S	TCGA-AB-2828	LAML	TCGA	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.P411S	DO21571	LAML	ICGC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.G448V	TCGA-AN-A03X	BRCA	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.0556
p.G448V	DO2885	BRCA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.0556
p.G418R	TCGA-C8-A1HJ	BRCA	TCGA	PPYY	ITCH	420:423	Mutation rewiring degron network	0.2778
p.G418R	DO1464	BRCA	ICGC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.2778
p.A501V	TCGA-D3-A8GI	SKCM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.6936
p.A502V	TCGA-DK-AA6M	BLCA	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.5825
p.P420L	TCGA-DX-A7ES	SARC	TCGA	PPYY	ITCH	420:423	Mutation altering degron motif	0.7582
p.P420L	DO220036	SARC	ICGC	PPYY	ITCH	420:423	Mutation altering degron motif	0.7582
p.P489Q	TCGA-EE-A2MK	SKCM	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2778
p.G505V	TCGA-EY-A1GU	UCEC	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.25
p.A412T	TCGA-EY-A215	UCEC	TCGA	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1111
p.A412T	DO42665	UCEC	ICGC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1111
p.G457R	TCGA-FR-A3YO	SKCM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.3056
p.G457R	TCGA-FR-A3YO	SKCM	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.1111
p.G457R	DO37419	SKCM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.3056
p.G457R	DO37419	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.1111
p.R463C	TCGA-FR-A726	SKCM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.719
p.R463C	DO48665	SKCM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.719
p.A473V	TCGA-FW-A3R5	SKCM	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6936
p.A473V	DO37819	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6936
p.A473V	DO37406	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6936
p.I453M	TCGA-HU-A4H4	STAD	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.1944
p.I453M	DO47721	STAD	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.1944
p.G498V	TCGA-WY-A859	LGG	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.6421
p.G498W	TCGA-WY-A859	LGG	TCGA	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.6714
p.R509C	DO51927	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1389
p.P500H	DO49800	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.7694
p.A486V	DO219003	BLCA	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1944
p.A486V	DO219003	BLCA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.1111
p.A510T	DO8730	COAD	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1111
p.A510T	SNU-1040	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1111
p.V470L	DO234392	ESAD	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6765
p.A501S	DO11986	GBM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.7588
p.A498V	DO12700	GBM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.6936
p.R475H	DO10880	GBM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7133
p.R475H	ACH-000958	Colon/Colorectal Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7133
p.R475H	SW48	large intestine	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7133
p.G482V	DO219859	LGG	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0833
p.G482V	DO219859	LGG	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.2222
p.G482W	DO219859	LGG	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0833
p.G482W	DO219859	LGG	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.2222
p.P414Q	DO228976	LICA	ICGC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1667
p.L465M	DO229045	LICA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5999
p.L465M	DO229045	LICA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.711
p.G469D	DO50970	LICA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6087
p.P479S	DO231607	LINC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.3056
p.P473L	DO231091	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6471
p.P473L	DO27112	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6471
p.D474Y	DO27112	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6214
p.A477G	DO31260	OV	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.6429
p.A485V	DO50284	SKCM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1667
p.A485V	DO50284	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.1389
p.R501C	DO51259	SKCM	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.8301
p.P473Q	DO38177	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.5924
p.A510V	DO38192	STAD	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1111
p.V413F	DO229229	THCA	ICGC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1389
p.G489V	DO41518	UCEC	ICGC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2778
p.R491G	SIDM00845	Burkitt's Lymphoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.7568
p.T461A	SIDM00845	Burkitt's Lymphoma	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.T461A	SIDM00461	Acute Myeloid Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.T461A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.T461A	SIDM01519	Head and Neck Carcinoma	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.6028
p.G476V	SIDM00120	Prostate Carcinoma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7532
p.G476V	DU-145	prostate	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation altering degron motif	0.7532
p.R432K	SIDM01242	Melanoma	GDSC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.R432K	ACH-002084	Skin Cancer	CCLE	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.R432K	ACH-002162	Skin Cancer	CCLE	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.R432K	MMAC-SF	skin	COSMIC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.0833
p.T481I	SIDM00704	Small Cell Lung Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.T481I	SIDM00704	Small Cell Lung Carcinoma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.T481I	SIDM01577	Plasma Cell Myeloma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.T481I	SIDM01577	Plasma Cell Myeloma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.T481I	NCI-H211	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.T481I	NCI-H211	lung	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.R454C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222
p.R454C	ACH-000920	Leukemia	CCLE	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222
p.R454C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRPTLRHLA	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222
p.L506V	SIDM00461	Acute Myeloid Leukemia	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2222
p.P414S	SIDM00140	Melanoma	GDSC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1667
p.P414S	ACH-000968	Skin Cancer	CCLE	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1667
p.P414S	COLO-792	skin	COSMIC	PPYY	ITCH	420:423	Mutation rewiring degron network	0.1667
p.P421S	SIDM00534	Colorectal Carcinoma	GDSC	PPYY	ITCH	420:423	Mutation altering degron motif	0.6752
p.P421S	ACH-000986	Colon/Colorectal Cancer	CCLE	PPYY	ITCH	420:423	Mutation altering degron motif	0.6752
p.P421S	HT-115	large intestine	COSMIC	PPYY	ITCH	420:423	Mutation altering degron motif	0.6752
p.Q511H	SIDM01617	Endometrial Carcinoma	GDSC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0833
p.A481S	ACH-000945	Lung Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.A481S	ACH-000945	Lung Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.A481S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.A481S	NCI-H650	lung	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.R489W	ACH-000963	Colon/Colorectal Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2778
p.R489W	CCK-81	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.2778
p.Q495H	ACH-000994	Endometrial/Uterine Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.647
p.A481T	ACH-000999	Colon/Colorectal Cancer	CCLE	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.A481T	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.A481T	SNU-1040	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.0556
p.A481T	SNU-1040	large intestine	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	465:478	Mutation rewiring degron network	0.25
p.G418E	ACH-001991	Primary	CCLE	PPYY	ITCH	420:423	Mutation rewiring degron network	0.2778
p.A497S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.7588
p.R505W	CCK-81	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.25
p.A510S	NCI-H650	lung	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation rewiring degron network	0.1111
p.A497T	SNU-1040	large intestine	COSMIC	TDSCQSGGVPTA	DEG_COP1_1	491:502	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PABPC4

UniProt ID: Q13310

Entrez ID: 8761

Protein name: Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PABPC4 in