DegronMD

Uniprot ID: Q13310

Source protein: Polyadenylate-binding protein 4

Source gene: PABPC4

Class: DEG_ODPH_VHL_1

Location: 465:478

E3 ligase: VHL

DEGRON score: 0.9736

ASA_SCORE: 60.7071

COIL: 0.807

CONS_SCORE: 0.2531

DSS_SCORE: 0.5716

HELIX: 0.121

FCONS_SCORE: 0.9014

RIG_SCORE: 0.708

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A466T	TCGA-AA-3950	COAD	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7139
p.A466T	DO9202	COAD	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7139
p.A466T	DO233135	GACA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7139
p.G457R	TCGA-FR-A3YO	SKCM	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.1111
p.G457R	DO37419	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.1111
p.A473V	TCGA-FW-A3R5	SKCM	TCGA	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6936
p.A473V	DO37819	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6936
p.A473V	DO37406	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6936
p.A486V	DO219003	BLCA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.1111
p.V470L	DO234392	ESAD	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6765
p.R475H	DO10880	GBM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7133
p.R475H	ACH-000958	Colon/Colorectal Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7133
p.R475H	SW48	large_intestine	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7133
p.G482V	DO219859	LGG	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.2222
p.G482W	DO219859	LGG	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.2222
p.L465M	DO229045	LICA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.711
p.G469D	DO50970	LICA	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6087
p.P479S	DO231607	LINC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.3056
p.P473L	DO231091	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6471
p.P473L	DO27112	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6471
p.D474Y	DO27112	LUSC	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6214
p.A477G	DO31260	OV	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.6429
p.A485V	DO50284	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.1389
p.P473Q	DO38177	SKCM	ICGC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.5924
p.G476V	SIDM00120	Prostate Carcinoma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7532
p.G476V	DU-145	prostate	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.7532
p.T481I	SIDM00704	Small Cell Lung Carcinoma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.T481I	SIDM01577	Plasma Cell Myeloma	GDSC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.T481I	NCI-H211	lung	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.A481S	ACH-000945	Lung Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.A481S	NCI-H650	lung	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.A481T	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25
p.A481T	SNU-1040	large_intestine	COSMIC	LAPTGSECPDRLAM	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPTGSECPDRLAM

Degron related mutations and impact score

Drug responses associated with PABPC4 mutations

All proteins holding degron of LAPTGSECPDRLAM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13310	Polyadenylate-binding protein 4	DEG_ODPH_VHL_1	465:478	LAPTGSECPDRLAM	VHL	0.9736	More...