DegronMD

Uniprot ID: Q13310

Source protein: Polyadenylate-binding protein 4

Source gene: PABPC4

Class: DEG_APCC_DBOX_1

Location: 458:466

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9132

ASA_SCORE: 70.5778

COIL: 0.8807

CONS_SCORE: 0.2976

DSS_SCORE: 0.7128

HELIX: 0.0582

FCONS_SCORE: 0.9976

RIG_SCORE: 0.6526

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R463H	TCGA-76-4929	GBM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.R463H	TCGA-AB-2806	LAML	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.R463H	TCGA-F5-6814	READ	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.R463H	DO12772	GBM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.R463H	DO21283	LAML	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.R463H	DO36556	READ	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.7133
p.A466T	TCGA-AA-3950	COAD	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.A466T	DO9202	COAD	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.A466T	DO233135	GACA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.G448V	TCGA-AN-A03X	BRCA	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.0556
p.G448V	DO2885	BRCA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.0556
p.G457R	TCGA-FR-A3YO	SKCM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.3056
p.G457R	DO37419	SKCM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.3056
p.R463C	TCGA-FR-A726	SKCM	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.719
p.R463C	DO48665	SKCM	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.719
p.I453M	TCGA-HU-A4H4	STAD	TCGA	PRPTLRHLA	DEG_APCC_DBOX_1	0.1944
p.I453M	DO47721	STAD	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.1944
p.L465M	DO229045	LICA	ICGC	PRPTLRHLA	DEG_APCC_DBOX_1	0.5999
p.T461A	SIDM00845	Burkitt's Lymphoma	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.T461A	SIDM00461	Acute Myeloid Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.T461A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.T461A	SIDM01519	Head and Neck Carcinoma	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	0.6028
p.R454C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRPTLRHLA	DEG_APCC_DBOX_1	0.2222
p.R454C	ACH-000920	Leukemia	CCLE	PRPTLRHLA	DEG_APCC_DBOX_1	0.2222
p.R454C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRPTLRHLA	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13310	Polyadenylate-binding protein 4	DEG_APCC_DBOX_1	458:466	PRPTLRHLA	APC,CDC20,FZR1	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRPTLRHLA

Degron related mutations and impact score

Drug responses associated with PABPC4 mutations

All proteins holding degron of PRPTLRHLA