DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPYY
Uniprot ID:
Q13310
Source protein:
Polyadenylate-binding protein 4
Source gene:
PABPC4
Class:
ITCH
Location:
420:423
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9823
ASA_SCORE:
27.25
COIL:
0.82
CONS_SCORE:
0.3612
DSS_SCORE:
0.5735
HELIX:
0.0175
FCONS_SCORE:
1.1599
RIG_SCORE:
0.7104
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P411S
TCGA-AB-2828
LAML
TCGA
PPYY
ITCH
0.0833
p.P411S
DO21571
LAML
ICGC
PPYY
ITCH
0.0833
p.G418R
TCGA-C8-A1HJ
BRCA
TCGA
PPYY
ITCH
0.2778
p.G418R
DO1464
BRCA
ICGC
PPYY
ITCH
0.2778
p.P420L
TCGA-DX-A7ES
SARC
TCGA
PPYY
ITCH
0.7582
p.P420L
DO220036
SARC
ICGC
PPYY
ITCH
0.7582
p.A412T
TCGA-EY-A215
UCEC
TCGA
PPYY
ITCH
0.1111
p.A412T
DO42665
UCEC
ICGC
PPYY
ITCH
0.1111
p.P414Q
DO228976
LICA
ICGC
PPYY
ITCH
0.1667
p.V413F
DO229229
THCA
ICGC
PPYY
ITCH
0.1389
p.R432K
SIDM01242
Melanoma
GDSC
PPYY
ITCH
0.0833
p.R432K
ACH-002084
Skin Cancer
CCLE
PPYY
ITCH
0.0833
p.R432K
ACH-002162
Skin Cancer
CCLE
PPYY
ITCH
0.0833
p.R432K
MMAC-SF
skin
COSMIC
PPYY
ITCH
0.0833
p.P414S
SIDM00140
Melanoma
GDSC
PPYY
ITCH
0.1667
p.P414S
ACH-000968
Skin Cancer
CCLE
PPYY
ITCH
0.1667
p.P414S
COLO-792
skin
COSMIC
PPYY
ITCH
0.1667
p.P421S
SIDM00534
Colorectal Carcinoma
GDSC
PPYY
ITCH
0.6752
p.P421S
ACH-000986
Colon/Colorectal Cancer
CCLE
PPYY
ITCH
0.6752
p.P421S
HT-115
large_intestine
COSMIC
PPYY
ITCH
0.6752
p.G418E
ACH-001991
Primary
CCLE
PPYY
ITCH
0.2778
Drug responses associated with PABPC4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPYY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94915
Protein furry homolog-like
ITCH
1462:1465
PPYY
ITCH,NEDD4
0.9735
More...
P13611
Versican core protein
ITCH
2804:2807
PPYY
ITCH,NEDD4
0.882
More...
P13942
Collagen alpha-2
ITCH
277:280
PPYY
ITCH,NEDD4
0.9939
More...
P23771
Trans-acting T-cell-specific transcription factor GATA-3
ITCH
61:64
PPYY
ITCH,NEDD4
0.9955
More...
P37231
Peroxisome proliferator-activated receptor gamma
ITCH
113:116
PPYY
ITCH,NEDD4
0.5611
More...
P67809
Y-box-binding protein 1
ITCH
194:197
PPYY
ITCH,NEDD4
0.9958
More...
Q13310
Polyadenylate-binding protein 4
ITCH
420:423
PPYY
ITCH,NEDD4
0.9823
More...
Q6ZTQ4
Cadherin-related family member 3
ITCH
438:441
PPYY
ITCH,NEDD4
0.6494
More...
Q7Z7F0
KH homology domain-containing protein 4
ITCH
352:355
PPYY
ITCH,NEDD4
0.92
More...
Q96AW1
Vesicular, overexpressed in cancer, prosurvival protein 1
ITCH
116:119
PPYY
ITCH,NEDD4
0.6737
More...
Q99439
Calponin-2
ITCH
300:303
PPYY
ITCH,NEDD4
0.9844
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
834:837
PPYY
ITCH,NEDD4
0.9444
More...
Q9H040
DNA-dependent metalloprotease SPRTN
ITCH
177:180
PPYY
ITCH,NEDD4
0.7657
More...
Q9NRM1
Enamelin
ITCH
212:215
PPYY
ITCH,NEDD4
0.6712
More...
Q9P0X4
Voltage-dependent T-type calcium channel subunit alpha-1I
ITCH
254:257
PPYY
ITCH,NEDD4
0.5243
More...
Q9Y6H8
Gap junction alpha-3 protein
ITCH
269:272
PPYY
ITCH,NEDD4
0.9959
More...
P55808
Glycoprotein Xg
ITCH
50:53
PPYY
ITCH,NEDD4
0.8102
More...
Q5JSJ4
Integrator complex subunit 6-like
ITCH
424:427
PPYY
ITCH,NEDD4
0.9555
More...