DegronMD - Q99439(CNN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G282V	TCGA-5M-AAT6	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.1389
p.G282V	TCGA-D3-A2J6	SKCM	TCGA	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.1389
p.E298D	TCGA-AA-3492	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.5647
p.P293S	TCGA-FW-A3R5	SKCM	TCGA	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.5641
p.G288C	TCGA-QG-A5Z2	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.3056
p.E287D	DO8224	COAD	ICGC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.2778
p.C279S	DO224627	LAML	ICGC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.0556
p.P289L	DO229177	LMS	ICGC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.7582
p.P282S	DO37406	SKCM	ICGC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.1389
p.T299I	SIDM00578	Neuroblastoma	GDSC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.7078
p.T299I	NB1	autonomic ganglia	COSMIC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.7078
p.C311Y	SIDM00633	Breast Carcinoma	GDSC	PPYY	ITCH	300:303	Mutation rewiring degron network	0.1111
p.V296F	ACH-001707	Leukemia	CCLE	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.7068
p.A307V	ACH-001719	Ovarian Cancer	CCLE	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation rewiring degron network	0.1111
p.A307V	ACH-001719	Ovarian Cancer	CCLE	PPYY	ITCH	300:303	Mutation rewiring degron network	0.2222
p.K293R	NCI-H630	large intestine	COSMIC	DCPDPGEVPEY	DEG_COP1_1	289:299	Mutation altering degron motif	0.7237

Kaplan plot for CNN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNN2

UniProt ID: Q99439

Entrez ID: 1265

Protein name: Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNN2 in