DegronMD

Uniprot ID: Q99439

Source protein: Calponin-2

Source gene: CNN2

Class: DEG_COP1_1

Location: 289:299

E3 ligase: COP1

DEGRON score: 0.9985

ASA_SCORE: 75.7182

COIL: 0.9241

CONS_SCORE: 0.3237

DSS_SCORE: 0.6753

HELIX: 0.0375

FCONS_SCORE: 1.0075

RIG_SCORE: 0.6562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G282V	TCGA-5M-AAT6	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	0.1389
p.G282V	TCGA-D3-A2J6	SKCM	TCGA	DCPDPGEVPEY	DEG_COP1_1	0.1389
p.E298D	TCGA-AA-3492	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	0.5647
p.P293S	TCGA-FW-A3R5	SKCM	TCGA	DCPDPGEVPEY	DEG_COP1_1	0.5641
p.G288C	TCGA-QG-A5Z2	COAD	TCGA	DCPDPGEVPEY	DEG_COP1_1	0.3056
p.E287D	DO8224	COAD	ICGC	DCPDPGEVPEY	DEG_COP1_1	0.2778
p.C279S	DO224627	LAML	ICGC	DCPDPGEVPEY	DEG_COP1_1	0.0556
p.P289L	DO229177	LMS	ICGC	DCPDPGEVPEY	DEG_COP1_1	0.7582
p.P282S	DO37406	SKCM	ICGC	DCPDPGEVPEY	DEG_COP1_1	0.1389
p.T299I	SIDM00578	Neuroblastoma	GDSC	DCPDPGEVPEY	DEG_COP1_1	0.7078
p.T299I	NB1	autonomic_ganglia	COSMIC	DCPDPGEVPEY	DEG_COP1_1	0.7078
p.V296F	ACH-001707	Leukemia	CCLE	DCPDPGEVPEY	DEG_COP1_1	0.7068
p.A307V	ACH-001719	Ovarian Cancer	CCLE	DCPDPGEVPEY	DEG_COP1_1	0.1111
p.K293R	NCI-H630	large_intestine	COSMIC	DCPDPGEVPEY	DEG_COP1_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99439	Calponin-2	DEG_COP1_1	289:299	DCPDPGEVPEY	COP1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons