DegronMD

Uniprot ID: Q7Z7F0

Source protein: KH homology domain-containing protein 4

Source gene: KHDC4

Class: ITCH

Location: 352:355

E3 ligase: ITCH,NEDD4

DEGRON score: 0.92

ASA_SCORE: 77.4

COIL: 0.9118

CONS_SCORE: 0.4313

DSS_SCORE: 0.5156

HELIX: 0.0213

FCONS_SCORE: 1.0038

RIG_SCORE: 0.6186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V348I	SIDM00845	Burkitt's Lymphoma	GDSC	PPYY	ITCH	0.2222
p.V348I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPYY	ITCH	0.2222
p.V348I	SIDM01519	Head and Neck Carcinoma	GDSC	PPYY	ITCH	0.2222
p.Q361L	SIDM01503	Small Cell Lung Carcinoma	GDSC	PPYY	ITCH	0.1667
p.T358I	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.25
p.S357G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.2778
p.T342A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPYY	ITCH	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94915	Protein furry homolog-like	ITCH	1462:1465	PPYY	ITCH,NEDD4	0.9735	More...
P13611	Versican core protein	ITCH	2804:2807	PPYY	ITCH,NEDD4	0.882	More...
P13942	Collagen alpha-2	ITCH	277:280	PPYY	ITCH,NEDD4	0.9939	More...
P23771	Trans-acting T-cell-specific transcription factor GATA-3	ITCH	61:64	PPYY	ITCH,NEDD4	0.9955	More...
P37231	Peroxisome proliferator-activated receptor gamma	ITCH	113:116	PPYY	ITCH,NEDD4	0.5611	More...
P67809	Y-box-binding protein 1	ITCH	194:197	PPYY	ITCH,NEDD4	0.9958	More...
Q13310	Polyadenylate-binding protein 4	ITCH	420:423	PPYY	ITCH,NEDD4	0.9823	More...
Q6ZTQ4	Cadherin-related family member 3	ITCH	438:441	PPYY	ITCH,NEDD4	0.6494	More...
Q7Z7F0	KH homology domain-containing protein 4	ITCH	352:355	PPYY	ITCH,NEDD4	0.92	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	116:119	PPYY	ITCH,NEDD4	0.6737	More...
Q99439	Calponin-2	ITCH	300:303	PPYY	ITCH,NEDD4	0.9844	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	834:837	PPYY	ITCH,NEDD4	0.9444	More...
Q9H040	DNA-dependent metalloprotease SPRTN	ITCH	177:180	PPYY	ITCH,NEDD4	0.7657	More...
Q9NRM1	Enamelin	ITCH	212:215	PPYY	ITCH,NEDD4	0.6712	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	ITCH	254:257	PPYY	ITCH,NEDD4	0.5243	More...
Q9Y6H8	Gap junction alpha-3 protein	ITCH	269:272	PPYY	ITCH,NEDD4	0.9959	More...
P55808	Glycoprotein Xg	ITCH	50:53	PPYY	ITCH,NEDD4	0.8102	More...
Q5JSJ4	Integrator complex subunit 6-like	ITCH	424:427	PPYY	ITCH,NEDD4	0.9555	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons